Looking for a bit of co-action?

Blakey, John D.
March 2007
Thorax;Mar2007, Vol. 62 Issue 3, p196
Academic Journal
The article comments on H.-W. Park and colleagues' paper about the use of multifactor-dimensionality reduction (MDR) as a primary tool for multilocus analyses of atopy in children. Park and colleagues used MDR and the related technique of combinatorial partitioning to study the relationship between an intermediate phenotype and both single and multilocus genotypes in a large population.


Related Articles

  • Preliminary evidence for altered motion tracking-based hyperactivity in ADHD siblings. Reh, Verena; Schmidt, Martin; Rief, Winfried; Christiansen, Hanna // Behavioral & Brain Functions;2014, Vol. 10 Issue 1, p1 

    Background: It is well-established that ADHD children have deficits in executive functions such as performance variability and sustained attention. It has been suggested that these deficits are intermediate phenotypes. Hyperactivity, a core symptom of ADHD, has not yet been explored as a...

  • Association of clinical and genetical features in FMF with focus on MEFV strip assay sensitivity in 452 children from western Anatolia, Turkey. Ozturk, Can; Halıcıoglu, Oya; Coker, Işıl; Gulez, Nesrin; Sutçuoglu, Sumer; Karaca, Neslihan; Aksu, Guzide; Kutukculer, Necil // Clinical Rheumatology;Mar2012, Vol. 31 Issue 3, p493 

    The aim of this study was to determine the relationship between clinical findings and the most common mutated alleles of MEFV gene in a childhood population and to determine the sensitivity of the 12-mutation-strip assay test in familial Mediterranean fever (FMF). Records of 452 FMF children...

  • The spectrum of anorectal malformations in Africa. Moore, S. W.; Alexander, A.; Sidler, D.; Alves, J.; Hadley, G. P.; Numanoglu, A.; Banieghbal, B.; Chitnis, M.; Birabwa-Male, D.; Mbuwayesango, B.; Hesse, A.; Lakhoo, K. // Pediatric Surgery International;Jun2008, Vol. 24 Issue 6, p677 

    Anorectal malformations (ARM) remain a significant birth defect with geographic variation in incidence, individual phenotypes and regional geographic subtypes. Although early studies indicated a low incidence in Black patients, there is a great paucity of knowledge as to the types, frequency and...

  • Familial Mediterranean fever gene mutation frequencies and genotype-phenotype correlations in the Aegean region of Turkey. Ozalkaya, Elif; Mir, Sevgi; Sozeri, Betul; Berdeli, Afig; Mutlubas, Fatma; Cura, Alphan // Rheumatology International;Jun2011, Vol. 31 Issue 6, p779 

    Familial Mediterranean fever (FMF) is a disease characterized by recurrent, self-limiting fever and serositis and caused by altered pyrin due to mutated MEFV gene. The aim of this study was to investigate clinical manifestations and MEFV mutations among patients with FMF and healthy controls in...

  • Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis. Maria Kousi; Eija Siintola; Lenka Dvorakova; Hana Vlaskova; Julie Turnbull; Meral Topcu; Deniz Yuksel; Sarenur Gokben; Berge A. Minassian; Milan Elleder; Sara E. Mole; Anna-Elina Lehesjoki // Brain: A Journal of Neurology;Mar2009, Vol. 132 Issue 3, p810 

    The neuronal ceroid lipofuscinoses (NCLs), the most common neurodegenerative disorders of childhood, are characterized by the accumulation of autofluorescent storage material mainly in neurons. Although clinically rather uniform, variant late-infantile onset NCL (vLINCL) is genetically...

  • Recurrent Achalasia in a Child with Williams-Beuren Syndrome. Pereza, Nina; Barbarić, Irena; Ostojić, Saša; Čače, Neven; Kapović, Miljenko // Collegium Antropologicum;Sep2011, Vol. 35 Issue 3, p941 

    Williams-Beuren syndrome is a multysistem genetic disorder caused by the 1.6Mb hemizygous deletion involving the elastin gene in the region q11.23 of chromosome 7. The phenotype of Williams-Beuren syndrome is extremelly variable but the most common findings include cardiovascular disease,...

  • AWT1exon 1 mutation in a child diagnosed with Denys-Drash syndrome. Little, Suzanne; Hanks, Sandra; King-Underwood, Linda; Picton, Sue; Cullinane, Catherine; Rapley, Elizabeth; Rahman, Nazneen; Pritchard-Jones, Kathy // Pediatric Nephrology;Jan2005, Vol. 20 Issue 1, p81 

    Denys-Drash syndrome (DDS) is characterized by nephropathy, genital abnormalities, and predisposition to Wilms tumor. DDS is associated with constitutionalWT1mutations, the majority being missense mutations in the zinc-finger region. A dominant-negative mode of action of the mutant DDS proteins...

  • Effects of Chronic Ascariasis and Trichuriasis on Cytokine Production and Gene Expression in Human Blood: A Cross-Sectional Study. Ortiz, Miguel Reina; Schreiber, Fernanda; Benitez, Susana; Broncano, Nely; Chico, Martha E.; Vaca, Maritza; Alexander, Neal; Lewis, David J.; Dougan, Gordon; Cooper, Philip J. // PLoS Neglected Tropical Diseases;Jun2011, Vol. 5 Issue 6, p1 

    Background: Chronic soil-transmitted helminth (STH) infections are associated with effects on systemic immune responses that could be caused by alterations in immune homeostasis. To investigate this, we measured the impact in children of STH infections on cytokine responses and gene expression...

  • Gain of Chromosome 4qter and Loss of 5pter: An Unusual Case with Features of Cri du Chat Syndrome. Sheth, Frenny; Gohel, Naresh; Liehr, Thomas; Akinde, Olakanmi; Desai, Manisha; Adeteye, Olawaleye; Sheth, Jayesh // Case Reports in Genetics;2012, p1 

    Here, we present a case with an unusual chromosomal rearrangement in a child with a predominant phenotype of high-pitched crying showing deletion encompassing CTNND2 due to an unbalanced translocation of chromosomes 4 and 5. This rearrangement led to a duplication of~35Mb in 4qter which replaced...


Read the Article


Sign out of this library

Other Topics