New Studies on the Role of Smoking in Inflammatory Bowel Disease: Are We Not Beating a Dead Horse?

Picco, Michael F.
March 2007
American Journal of Gastroenterology;Mar2007, Vol. 102 Issue 3, p598
Academic Journal
The role of smoking in inflammatory bowel disease (IBD) has drawn more interest as our understanding of these diseases has moved beyond the simple designations of Crohn's disease (CD) and ulcerative colitis (UC). In this issue of the journal, Aldous et al. present two papers on the role of smoking in the heterogeneity of IBD. They confirm the findings of many, are at odds with the findings of some, and provide novel observations for us all as we try to understand this complex interaction. Do these studies provide more clarity or just add to the noise? As always, the devil is in the details.


Related Articles

  • New susceptibility genes for ulcerative colitis. Dubois, Patrick C.; van Heel, David A. // Nature Genetics;Jun2008, Vol. 40 Issue 6, p686 

    Genome-wide association studies in Crohn's disease have convincingly identified multiple risk variants. Two new studies in ulcerative colitis, a related inflammatory bowel disease, now reveal a glimpse of the overlapping spectrum of risk variants, highlighting both the commonalities and the...

  • Utilization of Health-Care Resources by Patients With IBD in Manitoba: A Profile of Time Since Diagnosis. Longobardi, Teresa; Bernstein, Charles N. // American Journal of Gastroenterology;Aug2007, Vol. 102 Issue 8, p1683 

    OBJECTIVES: We tested the hypothesis of nonlinear longitudinal trends in health-care utilization by individuals with Crohn's disease (CD) and ulcerative colitis (UC) in Manitoba. METHODS: Administrative databases were used to report resource use in 2000/1. A total of 5,485 cases of CD and UC and...

  • Early surgical intervention in ulcerative colitis. Cima, R. R.; Pemberton, J. H. // Gut;Feb2004, Vol. 53 Issue 2, p306 

    This article focuses on the early surgical intervention in ulcerative colitis (UC), which is one of the major categories of inflammatory bowel disease and is characterised by chronic colonic mucosal inflammation of unknown aetiology. There are three major indications for surgical intervention in...

  • Diet and relapsing ulcerative colitis: take off the meat? Tilg, H.; Kaser, A. // Gut;Oct2004, Vol. 53 Issue 10, p1399 

    This article reports on the association of dietary factors such as red meat, high protein intake, and alcohol with relapse in ulcerative colitis. Major advances in the understanding of the aetiopathogenesis and genetics of inflammatory bowel disease have been accompanied by an increase in the...

  • The prevalence of ocular involvement in patients with inflammatory bowel disease. Yilmaz, Safiye; Aydemir, Ebru; Maden, Ahmet; Unsal, Belkis // International Journal of Colorectal Disease;Sep2007, Vol. 22 Issue 9, p1027 

    The aim of this prospective randomized clinical study was to evaluate the prevalence of ocular involvement in patients with inflammatory bowel disease (IBD). We prospectively evaluated 116 patients who went to the gastroenterology clinic with endoscopically proven IBD between December 2001 and...

  • Managing inflammatory bowel disease.  // Update;9/15/2005, Vol. 71 Issue 3, p30 

    The article presents information on the management of inflammatory bowel disease (IBD). Azathioprine and its metabolite mercaptopurine maintain remission of Crohn's and ulcerative colitis. These can treat frequent relapses, or flares on withdrawal of prednisolone. Shared-care protocols should...

  • VEGF-A isoform modulation in an preclinical TNBS model of ulcerative colitis: protective effects of a VEGF164b therapy. Cromer, Walter E.; Ganta, Chaitanya V.; Patel, Mihir; Traylor, James; Kevil, Christopher G.; Alexander, J. Steven; Mathis, J. Michael // Journal of Translational Medicine;2013, Vol. 11 Issue 1, p1 

    Background: Ulcerative colitis (UC) is the most common form of inflammatory bowel disease in the USA. A key component of UC is the increase in inflammatory angiogenesis of the colon during active disease. This increase is driven to a great extent by the over expression of VEGF-A. Recently,...

  • Clinical Expression of Inflammatory Bowel Diseases - A Retrospective Population-Based Cohort Study; Vukovarsko-Srijemska County, Croatia, 2010. Pezerović, Davorin; Žulj, Marinko; Klarin, Ivo; Majnarić, Ljiljana; Včev, Ivan; Včev, Aleksandar // Collegium Antropologicum;Sep2013, Vol. 37 Issue 3, p919 

    Clinical characteristics of the cohort of 150 patients with inflammatory bowel diseases, ulcerative colitis (UC) and Crohn's disease (CD), Vukovarsko-Srijemska County, Croatia, were retrospectively assessed. UC was clinically presented with frequent passage of bloody, slimy stools, while...

  • Inflammatory bowel disease. Jenkins, H. R. // Archives of Disease in Childhood;Nov2001, Vol. 85 Issue 5, p435 

    The epidemiology, aetiology, clinical features, diagnosis, and treatment of Crohn's disease and ulcerative colitis in children are reviewed, and areas for further research identified.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics