No Cure Yet for HIV-1, But Therapeutic Research Presses On

Schooley, Robert T.; Mellors, John W.
March 2007
Journal of Infectious Diseases;3/15/2007, Vol. 195 Issue 6, p770
Academic Journal
The article focuses on the author's comment regarding the study conducted by Siliciano et al. that used sensitive culture methods to further evaluate whether the use of valproic acid might activate HIV-1 from infected CD4 memory T-cells, which reduces the size of the latent viral reservoir in persons with chronic HIV-1 infection. According to the author, the work of Siliciano et. al does not support the previous findings published by Lehman et al.


Related Articles

  • Severe Anemia Secondary to a Probable Drug Interaction between Zidovudine and Valproic Acid. Antonio, Tony; Gough, Kevin; Yoong, Deborah; Arbess, Gordon // Clinical Infectious Diseases;3/1/2004, Vol. 38 Issue 5, pe38 

    A 42-year-old man with human immunodeficiency virus (HIV) infection and a history of complex partial seizures developed severe anemia after the addition of valproic acid to his stable antiretroviral regimen of zidovudine, lamivudine, and abacavir. The inhibition of zidovudine glucuronidation by...

  • Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. McCormack, E; Haaland, I; Venås, G; Forthun, R B; Huseby, S; Gausdal, G; Knappskog, S; Micklem, D R; Lorens, J B; Bruserud, Ø; Gjertsen, B T // Leukemia (08876924);May2012, Vol. 26 Issue 5, p910 

    Although TP53 mutations are rare in acute myeloid leukemia (AML), wild type p53 function is habitually annulled through overexpression of MDM2 or through various mechanisms including epigenetic silencing by histone deacetylases (HDACs). We hypothesized that co-inhibition of MDM2 and HDACs, with...

  • Valproic acid.  // Reactions Weekly;3/3/2012, Issue 1391, p40 

    The article describes the case of a 30-year-old woman who developed acrocyanosis and nail disorders while under valproic acid treatment regimen for recurrent convulsions.

  • Valproic acid inhibits human hepatocellular cancer cells growth in vitro and in vivo. Cesar Machado, Marcel Cerqueira; Bellodi-Privato, Marta; Kubrusly, Márcia Saldanha; Trindade Molan, Nilza Aparecida; Junior, Tharcisio Tortelli; de Oliveira, Erika Rodrigues; Carneiro D'Albuquerque, Luiz Augusto // Journal of Experimental Therapeutics & Oncology;2011, Vol. 9 Issue 2, p85 

    Background: Valproic acid (VPA) a histone deacetylase inhibitor has been shown to inhibit the growth of a variety of cancer cells. We examined the effect of VPA in human hepatocellular cancer cells (HUH7) in vitro and in vivo. We hypothesized that VPA may be able to modulate Notch-1 signaling in...

  • Sodium Valproate Alleviates Neurodegeneration in SCA3/MJD via Suppressing Apoptosis and Rescuing the Hypoacetylation Levels of Histone H3 and H4. Jiping Yi; Li Zhang; Beisha Tang; Weiwei Han; Yafang Zhou; Zhao Chen; Dandan Jia; Hong Jiang // PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1 

    Spinocerebellar ataxia type 3 (SCA3) also known as Machado-Joseph Disease (MJD), is one of nine polyglutamine (polyQ) diseases caused by a CAG-trinucelotide repeat expansion within the coding sequence of the ATXN3 gene. There are no disease-modifying treatments for polyQ diseases. Recent studies...

  • Stability of the Latent Reservoir for HIV-1 in Patients Receiving Valproic Acid. Siliciano, Janet D.; Jun Lai; Callender, Marc; Pitt, Eleanor; Hao Zhang; Margolick, Joseph B.; Gallant, Joel E.; Cofrancesco Jr., Joseph; Moore, Richard D.; Gange, Stephen J.; Siliciano, Robert F. // Journal of Infectious Diseases;3/15/2007, Vol. 195 Issue 6, p833 

    In light of a recent report that short-term treatment with valproic acid (VA) might accelerate the decay of the latent reservoir for HIV-1 in patients receiving combination therapy and allow eventual eradication of the infection, we studied patients with prolonged suppression of viremia who were...

  • 3',4'-Dimethoxyflavone and valproic acid promotes the proliferation of human hematopoietic stem cells. Kaur, Kiranpreet; Mirlashari, Mohammad Reza; Kvalheim, Gunnar; Kjeldsen-Kragh, Jens // Stem Cell Research & Therapy;2013, Vol. 4 Issue 3, p1 

    Introduction: Human hematopoietic stem cells (HSCs) have been clinically used for transplantation and gene and cellular therapy for more than 4 decades. However, this use is limited because of the challenges in the ex vivo culturing of HSCs. The major hurdle is to amplify these cells without...

  • Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL.  // Journal of Biomedical Science;2011, Vol. 18 Issue 1, p48 

    The article presents a study on cell death regulation during developmental stages of neural progenitor cells (NPCs). In this study NPCs were cultured, and NPC cell death was analyzed in pregnant in vivo valproic acid (VPA) animal models. Results indicated reduced death of NPC by VPA during...

  • Acute influence of sodium valproate on sodium and chloride urinary excretion in rats. Grikiniene, Jurgita; Stakisaitis, Donatas; Tschaika, Marina // Acta Medica Lituanica;2005, Vol. 12 Issue 2, p45 

    There is increasing evidence indicating that certain drugs evoke adverse drug effects that depend on the gender of patients. Elucidation of gender-effect of various drugs by means of preclinical trials is an important field of pharmacology. The chloriuretic and natriuretic effect of valproates...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics