NOD2 mutations and Crohn's disease: are Paneth cells and their antimicrobial peptides the link?

Grimm, M. C.; Pavli, P.
November 2004
Gut;Nov2004, Vol. 53 Issue 11, p1558
Academic Journal
The article examines if there is an association of Paneth cells and their antimicrobial peptides in NOD2 mutations and Crohn's disease. According to the authors, there is manifestation that NOD2 variants in Crohn's disease are associated with atrophied mucosal Α-defensin production, leading in impaired innate immunity. To give more light on the matter, discussions and implications of their study are presented.


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