TITLE

COX-2: a link between airway inflammation and disordered chloride secretion in cystic fibrosis?

AUTHOR(S)
Clayton, A.; Knox, A .J.
PUB. DATE
July 2006
SOURCE
Thorax;Jul2006, Vol. 61 Issue 7, p552
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
The article presents the cyclooxygenase (COX) and its possible connection in the regulation of inflammation and bronchial damage caused by cystic fibrosis (CF).COX is responsible for the conversion of arachidonic acid into prostanoids, which serves as lipid mediators and are thought to have a role in regulating inflammation.
ACCESSION #
21715214

 

Related Articles

  • The effect of trinitrobenzene sulfonic acid on gut-derived smooth muscle cell arachidonic acid metabolism: role of endogenous prostanoids. Longo, W. E.; Smith, G. S.; Deshpande, Y.; Reickenberg, C.; Kaminski, D. L. // Mediators of Inflammation;Jun97, Vol. 6 Issue 3, p237 

    The contribution of smooth muscle cells as a potential source of eicosanoid production during inflammatory states remains to be elucidated. We investigated the effect of trinitrobenzene sulfonic acid (TNB), a known pro-inflammatory agent, on jejunal smooth muscle cell eicosanoid production....

  • Leukotriene Receptor Antagonists in Children with Cystic Fibrosis Lung Disease: Anti-Inflammatory and Clinical Effects. Schmitt-Grohé, Sabina; Zielen, Stefan // Pediatric Drugs;2005, Vol. 7 Issue 6, p353 

    Cystic fibrosis (CF) lung disease is characterized by chronic endobronchial infection resulting in progressive pulmonary destruction; this is a major cause of mortality and morbidity. Neutrophils are the primary effector cells responsible for the progressive deterioration of lung function....

  • Lipid Mediators: Lipoxin and Aspirin-Triggered 15-Epi-Lipoxins. Romano, Mario // Inflammation & Allergy - Drug Targets;Apr2006, Vol. 5 Issue 2, p81 

    Lipoxins (LX) and their 15-epimers, aspirin triggered lipoxins (ATL) are emerging as major promoters of resolution of the inflammatory reaction. These eicosanoids, that carry a tetraene chromophore, derive from sequential lipoxygenase (LO) metabolism of arachidonic acid. Three principal routes...

  • Sebaceous Glands and the Prostaglandin Pathway—Key Stones of an Exciting Mosaic. Zouboulis, Christos C. // Journal of Investigative Dermatology;Nov2005, Vol. 125 Issue 5, px 

    The article cites a study which reports on sebaceous glands and the prostaglandin pathway. It is informed that Prostaglandins (PG) are detected in virtually all organs and cells, whereas their enhanced release follows inflammatory mechanisms. PG synthesis also takes place in epidermal...

  • New Perspectives in the Modulation of the Eicosanoid Cascade in Inflammation. Clària, J.; López-Parra, M. // Letters in Drug Design & Discovery;Aug2005, Vol. 2 Issue 5, p391 

    Cyclooxygenase and 5-lipoxygenase pathways, which convert arachidonic acid into prostaglandins and leukotrienes, respectively, are the two major pro-inflammatory routes, whereas lipoxins, resolvins and neuroprotectins are potent endogenous anti-inflammatory mediators. Modulation of these...

  • New Approaches to the Modulation of the Cyclooxygenase-2 and 5-Lipoxygenase Pathways. Gonz�lez-P�riz, A.; Cl�ria, J. // Current Topics in Medicinal Chemistry;Feb2007, Vol. 7 Issue 3, p297 

    The eicosanoid family comprises a number of biologically active lipid mediators involved in the regulation of inflammation and cancer cell growth. Eicosanoid biosynthesis is usually initiated by the release of arachidonic acid (AA) from membrane phospholipids in response to the interaction of a...

  • Dual Carbonic Anhydrase - Cyclooxygenase-2 Inhibitors. Dogne, Jean-Michel; Thiry, Anne; Pratico, Domenico; Masereel, Bernard; Supuran, Claudiu T. // Current Topics in Medicinal Chemistry;May2007, Vol. 7 Issue 9, p885 

    Cyclooxygenase is a key enzyme responsible for metabolisation of arachidonic acid into prostaglandins and thromboxane. This enzyme is the target of non steroidal anti-inflammatory drugs (NSAIDs), used against inflammation and pain. The inducible COX-2 was associated with inflammatory conditions,...

  • A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans. Tomimoto, Hidekazu; Shibata, Masunari; Ihara, Masafumi; Akiguchi, Ichiro; Ohtani, Rho; Budka, Herbert // Acta Neuropathologica;Dec2002, Vol. 104 Issue 6, p601 

    Prostaglandins and leukotrienes (eicosanoids), metabolites of the arachidonic acid pathway, are subjected to altered synthesis or relocation after an ischemic insult. Although cyclooxygenase (COX) expression has been reported in human cerebral ischemia, no information is available on the...

  • Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2. Ke-He Ruan; Cervantes, Vanessa; Shui-Ping So // PEDS: Protein Engineering, Design & Selection;Dec2009, Vol. 22 Issue 12, p733 

    Cyclooxygenase isoform-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) are inducible enzymes that become up-regulated in inflammation and some cancers. It has been demonstrated that their coupling reaction of converting arachidonic acid (AA) into prostaglandin (PG) E2 (PGE2) is...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics