Ferrets and the Challenges of H5N1 Vaccine Formulation

Hampson, Alan W.
July 2006
Journal of Infectious Diseases;7/15/2006, Vol. 194 Issue 2, p143
Academic Journal
The author reflects on the use of ferrets and embryonated eggs and the challenges in developing egg-based influenza vaccines. A research revealed that ferrets and embryonated eggs may provide the basis for developing influenza vaccines that are important in preparation for bird flu pandemic. However, he argues that vaccination against the avian influenza viruses appears to be problematic. He also asserts that the global production of egg-based influenza vaccines is limited.


Related Articles

  • New Pre-pandemic Influenza Vaccines: An Egg- and Adjuvant-independent Human Adenoviral Vector Strategy Induces Long-lasting Protective Immune Responses in Mice. Hoelscher, M. A.; Jayashankar, L.; Garg, S.; Veguilla, V.; Lu, X.; Singh, N.; Katz, J. M.; Mittal, S. K.; Sambhara, S. // Clinical Pharmacology & Therapeutics;Dec2007, Vol. 82 Issue 6, p665 

    Highly pathogenic avian H5N1 influenza viruses that are currently circulating in southeast Asia may acquire the potential to cause the next influenza pandemic. A number of alternate approaches are being pursued to generate cross-protective, dose-sparing, safe, and effective vaccines, as...

  • Cross-protection and reassortment studies with avian H2 influenza viruses. Kaverin, N. V.; Smirnov, Y. A.; Govorkova, E. A.; Rudneva, I. A.; Gitelman, A. K.; Lipatov, A. S.; Varich, N. L.; Yamnikova, S. S.; Makarova, N. V.; Webster, R. G.; Lvov, D. K. // Archives of Virology;Jun2000, Vol. 145 Issue 6, p1059 

    Summary. In order to assess the degree of immune cross-protection among avian H2 influenza virus strains, mice were immunised with �-propiolactone-inactivated virus preparations and infected intranasally with mouse-adapted variant of A/Black Duck/New Jersey/1580/78 (H2N3) strain. The...

  • Avian flu vaccine. Murray, Sally // CMAJ: Canadian Medical Association Journal;9/13/2005, Vol. 173 Issue 6, p586 

    Reports on the test of an avian influenza vaccine by researchers at the U.S. National Institute of Allergy and Infectious Diseases. Number of people that were killed by the A(H5N1) strain of avian influenza virus.

  • Avian Influenza and the Significance of Us Transmission to Humans--Information from WHO.  // Journal of Environmental Health;Oct2005, Vol. 68 Issue 3, p41 

    The article presents information on Avian influenza. Avian influenza is caused by Type A strains of the influenza virus. First identified in Italy more than 100 years ago, the disease occurs worldwide. All birds are thought to be susceptible, although some species are more resistant to infection...

  • Recombinant Modified Vaccinia Virus Ankara--Based Vaccine Induces Protective Immunity in Mice against Infection with Influenza Virus H5N1. Kreijtz, Joost H. C. M.; Suezer, Yasemin; Van Amerongen, Geert; De Mutsert, Gerrie; Schnierle, Barbara S.; Wood, John M.; Kuiken, Thijs; Fouchier, Ron A. M.; Löwer, Johannes; Osterhaus, Albert D. M. E.; Sutter, Gerd; Rimmelzwaan, Guus F. // Journal of Infectious Diseases;6/1/2007, Vol. 195 Issue 11, p1598 

    Since 2003, the number of human cases of infections with highly pathogenic avian influenza viruses of the H5N1 subtype is still increasing, and, therefore, the development of safe and effective vaccines is considered a priority. However, the global production capacity of conventional vaccines is...

  • H5N1 Viruses and Vaccines. Subbarao, Kanta; Luke, Catherine // PLoS Pathogens;Mar2007, Vol. 3 Issue 3, p0264 

    The article focuses on the pandemic threat posed by the highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype and reviews the published data on the evaluation of H5N1 vaccines. A report by the World Health organization showed that as of January 29, 2007, 60% of the...

  • Avian influenza H5N1 virus infections in vaccinated commercial and backyard poultry in Egypt. Hafez, M. H.; Arafa, A.; Abdelwhab, E. M.; Selim, A.; Khoulosy, S. G.; Hassan, M. K.; Aly, M. M. // Poultry Science;Aug2010, Vol. 89 Issue 8, p1609 

    In this paper, we describe results from a high-pathogenic H5N1 avian influenza virus (AIV) surveillance program in previously H5-vaccinated commercial and family-backyard poultry flocks that was conducted from 2007 to 2008 by the Egyptian National Laboratory for Veterinary Quality Control on...

  • Best defence against avian flu is to fight the virus in Asia.  // Bulletin of the World Health Organization;Dec2005, Vol. 83 Issue 12, p887 

    The article focuses on several medical misconceptions related to the spread of avian flu in Asia. Poultry owners believe that avian flu affect only sick chickens. Government misinterprets that the outbreaks can be prevented by quickly vaccinating poultry animals through inexpensive drugs. This...

  • Think again Common misconceptions.  // New Scientist;1/7/2006, Vol. 189 Issue 2533, preceding p7 

    The article reports on misconceptions associated with bird flu. A regular flu shot will not help against bird flu. A pandemic vaccine is required if bird flu turned into a human pandemic. However, ordinary flu vaccination is a good idea for people closely exposed to birds with flu. More people...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics