TITLE

Vitamin D3 and response to glucocorticoids in steroid resistant asthmatics

AUTHOR(S)
Kon, S.
PUB. DATE
May 2006
SOURCE
Thorax;May2006, Vol. 61 Issue 5, p375
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
The article examines the effect of vitamin D3 and glucocorticoid therapy in steroid resistant asthmatics. The study shows that human interleukin (IL)-10 secreting regulatory T cells have the capacity to inhibit the immune response implicated in the pathogenesis of athma. It was shown also that dexamethasone downregulated glucocorticoid receptor expression. Vitamin D3 enhances IL-10 synthesis in glucocorticoid resistant patients.
ACCESSION #
21039831

 

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