Vitamin D3 and response to glucocorticoids in steroid resistant asthmatics

Kon, S.
May 2006
Thorax;May2006, Vol. 61 Issue 5, p375
Academic Journal
The article examines the effect of vitamin D3 and glucocorticoid therapy in steroid resistant asthmatics. The study shows that human interleukin (IL)-10 secreting regulatory T cells have the capacity to inhibit the immune response implicated in the pathogenesis of athma. It was shown also that dexamethasone downregulated glucocorticoid receptor expression. Vitamin D3 enhances IL-10 synthesis in glucocorticoid resistant patients.


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