The GATE frame: critical appraisal with pictures
- Bench and Bedside – The G Protein—Coupled Receptor GPR54 and Puberty. Beier, David R.; Dluhy, Robert G. // New England Journal of Medicine;10/23/2003, Vol. 349 Issue 17, p1589
The author discusses the implications of reports on biomarkers for patient care. The author says the measure should add information about the risk or prognosis. Assessment of risk can be done though case control and prospective cohort designs. It should also account for a large proportion of the...
- Biomarkers of Cervical Dysplasia and Carcinoma. Hwang, Sonya J.; Shroyer, Kenneth R. // Journal of Oncology;2012, p1
Although cervical cytology screening has decreased the incidence of cervical cancer in industrialized countries, HPV-related cervical disease, including premalignant and malignant lesions, continues to represent a major burden on the health care system. Some of the problems include the potential...
- Piling up Proteins to Improve Prognosis. May, Mike // Drug Discovery & Development;Oct2006, Vol. 9 Issue 10, pG10
The article focuses on the discovery of new protein biomarkers to improve diagnosis of variety of diseases in the U.S. Researchers in the field discussed the different strategies that are useful in detecting diseases ranging from Alzheimer's disease to cancer. Moreover, the standard for...
- Estimating the odds ratio when exposure has a limit of detection. Cole, Stephen R.; Haitao Chu; Lei Nie; Schisterman, Enrique F. // International Journal of Epidemiology;Dec2009, Vol. 38 Issue 6, p1674
Background In epidemiologic research, little emphasis has been placed on methods to account for left-hand censoring of â€˜exposuresâ€™ due to a limit of detection (LOD).
- Outcome prediction in severe burn injury: clinical versus laboratory markers. Brusselaers, N.; Monstrey, S.; Vogelaers, D.; Blot, S. // European Journal of Trauma & Emergency Surgery;Oct2011, Vol. 37 Issue 5, p533
No abstract available.
- Genomics at the Forefront of Biomarker Development for Prostate Cancer Detection and Therapeutics. Yadav, Shalini S.; Batra, Jaspreet S.; Tewari, Ashutosh K. // AUANews;Jan2014, Vol. 19 Issue 1, p1
The article discusses the need for the development of novel biomarkers for prostate cancer diagnosis and prognosis. An ideal biomarker would be quick to test, consistent, quantitative and cost-effective and should be readily detectable in bodily fluids and clinical samples. Key features of a...
- The Rocky Road to Useful Cancer Biomarkers. Wilson, Jennifer Fisher // Annals of Internal Medicine;6/20/2006, Vol. 144 Issue 12, p945
The article focuses on the biomarkers, the current clinical issue. Biomarkers is said to be the future of cancer treatment, allowing earlier diagnosis and more efficient and effective care. But according to physician Hal Moses, There are technical challenges associated with the validation and...
- Chest pain. Singer, Karl // Patient Care;Feb2003, Vol. 37 Issue 2, p6
Presents information on the significance of the quality of diagnostic test to come up with a correct diagnosis. Role of physicians in asserting the correct diagnosis; Information on a scenario where proper diagnosis was executed.
- The existential plight of cancer: meaning making as a concrete approach to the intangible search for meaning. // Supportive Care in Cancer;Jul2008, Vol. 16 Issue 7, p779
Abstract IntroductionÂ Â Despite modern advances that have led to improved prognoses and symptom management, a cancer diagnosis continues to evoke images of pain, suffering, and death. DiscussionÂ Â The current literature suggests that the â€œexistential plight of cancerâ€...