Susceptibility to HIV Infection--Disentangling Host Genetics and Host Behavior

Telenti, Amalio; Ioannidis, John P. A.
January 2006
Journal of Infectious Diseases;1/1/2006, Vol. 193 Issue 1, p4
Academic Journal
The article focuses on a study related to host genetics in HIV infection. In the study, published in the January 2006 issue of the "Journal of Infectious Diseases," researchers apply genetics along with explicit modeling of an "environmental" component to disentangle the nature and nurture of an individual's susceptibility to HIV-1. The study used standardized cumulative risk exposure measurement on a larger number of individuals. According to the author, the condition of being exposed uninfected appears to be particularly in tractable, because it grafts a multifactorial trait onto the poor efficiency of transmission of HIV-1 and the rarity of cohorts of individuals that are characterized as highly exposed and persistently seronegative.


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