TITLE

Potential role of platelet-activating factor in renal pathophysiology

AUTHOR(S)
Camussi, Giovanni
PUB. DATE
February 1986
SOURCE
Kidney International;Feb1986, Vol. 29 Issue 2, p469
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
The article role of platelet-activating factor (PAF) in renal pathology. PAF is a lipid chemical mediator that was discharged by antigen-stimulated IgE sensitized rabbit basophilis. It is indicated that PAF plays an essential function in the humoral and cellular effectors of inflammation and vascular homeostasis.
ACCESSION #
17693913

 

Related Articles

  • Platelet-derived chemokines: pathophysiology and therapeutic aspects. Flad, Hans-Dieter; Brandt, Ernst // Cellular & Molecular Life Sciences;Jul2010, Vol. 67 Issue 14, p2363 

    The identification of chemokines in blood platelets has strengthened our view of these cells as participants in immune host defense. Platelet chemokines representing prestored and rapidly releasable proteins may play a major role as first-line inflammatory mediators. This is evident from their...

  • Signalling, inflammation and arthritis: NF-{kappa}B and its relevance to arthritis and inflammation. R. E. Simmonds; B. M. Foxwell // Rheumatology;May2008, Vol. 47 Issue 5, p584 

    In the synovial cells of patients with RA, activation of the nuclear factor-κB (NF-κB) pathway results in the transactivation of a multitude of responsive genes that contribute to the inflammatory phenotype, including TNF-α from macrophages, matrix metalloproteinases from synovial...

  • A mutation in a CD44 variant of inflammatory cells enhances the mitogenic interaction of FGF with its receptor. Nedvetzki, Shlomo; Golan, Itshak; Assayag, Nathalie; Gonen, Erez; Caspi, Dan; Gladnikoff, Micha; Yayon, Avner; Naor, David // Journal of Clinical Investigation;4/15/2003, Vol. 111 Issue 8, p1211 

    Focuses on a study which examined the effect of a mutation in a CD44 variant of inflammatory cells on the mitogenic interaction of FGF with its receptor. Methods; Results; Discussion.

  • Pharmacological evidence supporting a role for IL-1, IL-2 and serotonin in the inflammation induced by Schistosoma mansoni Soluble Egg Antigen (SEA) in rat paws. Pacheco, C. M. F.; Tavares, C. A. P.; Coelho, P. M. Z.; Rocha, O. A.; Santos, J. M. M.; Prado, F. R. M.; Francischi, J. N. // Mediators of Inflammation;Aug98, Vol. 7 Issue 4, p261 

    THIS study intended to characterize pharmalogically the mediator(s) released in the inflammation induced by Soluble antigen released from eggs of Schistosoma mansoni, in rat hindpaws. A single intraplantar injection of 0.1-100 mu g SEA at day zero induced a dose-dependent increase in the volume...

  • INSTANT REFRESHERS: What you can learn from the platelet count. Silinsky, Janice J. // RN;Jan85, Vol. 48 Issue 1, p87 

    Focuses on the importance of blood platelet count as a diagnostic tool for patients. Role of platelets in homeostasis; Implications of platelet count; Procedures in counting platelets.

  • Effect of lipoprotein (a) on platelet activation induced by platelet-activating factor: role of apolipoprotein (a) and endogenous PAF-acetylhydrolase. Tsironis, Loukas D.; Mitsios, John V.; Milionis, Haralampos J.; Elisaf, Moses; Tselepis, Alexandros D. // Cardiovascular Research;Jul2004, Vol. 63 Issue 1, p130 

    Objective: Lipoprotein (a) [Lp(a)] is considered an atherogenic lipoprotein, which is also implicated in thrombosis. Lp(a) binds to platelets and modulates the effects of various platelet agonists. Platelet activating factor (PAF) is a potent platelet agonist degraded and inactivated by...

  • CR3 receptor on platelets and its role in the prostaglandin metabolic pathway. Cosgrove, Leah J.; d'Apice, Anthony J. F.; Haddad, Albert; Pedersen, John; McKenzie, Ian F. C. // Immunology & Cell Biology;Dec1987, Vol. 65 Issue 6, p453 

    The human C3R receptor, which binds C3bi, present on the surface of monocytes, granulocytes and natural killer cells, can be detected by several monoclonal antibodies, OKM1, Mol and Mac-1 and also by RM2.184 which detects a polymorphism of the receptor. Platelets have been considered to lack...

  • Negative Regulators of Toll-like Receptor 4-Mediated Macrophage Inflammatory Response. Butchar, Jonathan P.; Parsa, Kishore V.L.; Marsh, Clay B.; Tridandapani, Susheela // Current Pharmaceutical Design;Nov2006, Vol. 12 Issue 32, p4143 

    Activation of macrophages through TLR4, the receptor for the bacterial endotoxin LPS, results in a potent inflammatory response aimed at eliminating the invading pathogen. Excessive production of inflammatory mediators is harmful to host tissue and in extreme cases can result in fatal outcomes....

  • Origin and physiological roles of inflammation. Medzhitov, Ruslan // Nature;7/24/2008, Vol. 454 Issue 7203, p428 

    Inflammation underlies a wide variety of physiological and pathological processes. Although the pathological aspects of many types of inflammation are well appreciated, their physiological functions are mostly unknown. The classic instigators of inflammation — infection and tissue injury...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics