Mechanisms of cell volume regulation by the mouse medullary thick ascending limb of Henle

Sun, Adam M.; Saltzberg, Samuel N.; Kikeri, Deepak; Hebert, Steven C.
December 1990
Kidney International;Dec1990, Vol. 38 Issue 6, p1019
Academic Journal
The article focuses on medullary thick ascending limb of Henle (MTAL), a model for the study of renal epithelial cell volume regulation. Certain organic solutes such as sugars, amino acids, polyols and methylamines are accumulated, albeit slowly, in the renal medulla during hypertonic stress. Although the concentrations of some of these osmolytes in MTAL cells appear to be significantly greater than plasma during antidiuresis, the specific role(s) of these organic osmolytes in cell volume regulation in the MTAL and how these organic solutes may affect inorganic ion accumulation are unknown at present.


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