Declining Gastrointestinal Opportunistic Infections in HIV-Infected Persons: A Triumph of Science and a Challenge for Our HAARTs and Minds

Raufman, Jean-Pierre
July 2005
American Journal of Gastroenterology;Jul2005, Vol. 100 Issue 7, p1455
Academic Journal
Gastrointestinal opportunistic infections, primarily oral and esophageal candidiasis, are common in persons infected with the human immunodeficiency virus (HIV) and contribute significantly to morbidity and mortality. Research early in the AIDS epidemic established a strong association between the presence of oral and esophageal candidiasis in patients complaining of odynophagia, demonstrated the diagnostic efficacy of a therapeutic trial with anti-fungal medicines, and defined the indications for endoscopy in HIV-infected persons with upper gastrointestinal complaints. Resulting diagnostic and treatment strategies with anti-fungal agents were very effective in preventing and treating mycotic infections of the gastrointestinal tract. Now, robust data from the United States and Europe indicate that recent advances in the development and use of highly active anti-retroviral therapy (HAART) are associated with a striking decline in the prevalence of oro-esophageal candidiasis in HIV-infected persons. In addition to developing more effective, safer antiviral agents, an HIV vaccine, and other novel approaches to combating this illness, a major challenge is to provide HAART to those without access to these life-saving drugs. (Am J Gastroenterol 2005;100:1–4)


Related Articles

  • Relationship of HCV Infection to Mortality In Families. Winslow, Dean L. // Infectious Disease Alert;Mar2007, Vol. 26 Issue 6, p64 

    437 siblings of HIV/HCV-coinfected patients, 1856 siblings of HIV-monoinfected patients, and 285,509 siblings of control subjects were studied. Mortality was significantly higher in siblings of HCV-coinfected patients than either siblings of HIV-monoinfected patients or siblings of controls.

  • HIV-AN: An Important Renal Complication of HIV Infection in Blacks. Shahinian, V.; Rajamaran, S.; Borucki, M. // Kidney;Nov/Dec2000, Vol. 9 Issue 6, p251 

    Focuses on a study which determined the presence of HIV-associated nephropathy from autopsy data of HIV-infected patients in order to assess the impact of treatment options on morbidity and mortality. Methodology; Results; Conclusion.

  • Induction of a Soluble Anti-HIV-1 factor (s) with IFN-γ, IL-10, and β-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic Mixture. Rodríguez, José W.; Pagan, Nat O.; Ocasio, María C.; Ríos, Zilka; Cubano, Luis A.; Boukli, Nawal M.; Otero, Miguel; Hunter, Robert; Nair, Madhavan P.; Rios-Olivares, Eddy // American Journal of Infectious Diseases;2007, Vol. 3 Issue 4, p266 

    Partial immune restoration may be obtained with highly active antiretroviral therapy (HAART), but specific anti-HIV-1 immune responses do not appear to improve substantially. We have demonstrated that a soluble factor(s) induced by a mixture of inactivated influenza and bacterial vaccines called...

  • Vaccine made from HIV fragments bolsters immune response. Joyce, Christopher // New Scientist;6/22/91, Vol. 130 Issue 1774, p24 

    Reveals that experiments have indicated that the immune systems of people infected with HIV may be bolstered by vaccinations with a fragment of the virus. Possible effect of HIV's protein coat on the immune system; Vaccine developed by MicroGeneSys; Safety trials of the vaccine in uninfected...

  • HIV Type 1 RNA Level as a Clinical Indicator of Renal Pathology in HIV-Infected Patients. Estrella, Michelle; Fine, Derek M.; Gallant, Joel E.; Rahman, M. Hafizur; Nagajothi, Nagapradeep; Racusen, Lorraine C.; Scheel, Paul J.; Atta, Mohamed G. // Clinical Infectious Diseases;8/1/2006, Vol. 43 Issue 3, p377 

    To determine the value of human immunodeficiency virus type 1 (HIV-1) RNA level in distinguishing HIV-associated nephropathy from non-HIV-associated nephropathy renal pathological conditions, we retrospectively compared renal histopathological findings for 86 HIV-infected patients according to...

  • HCV Does Not Accelerate HIV Progression or Impede Treatment.  // Guide;Aug2006, Vol. 26 Issue 8, p65 

    The article discusses the study regarding impede treatment of HIV on Hepatitis C Virus. HIV is known to increase the severity of hepatitis C infection. According to the results of a massive study by researchers from the U.S. Centers for Disease Control and Prevention that hepatitis C virus does...

  • Chapter 1: Overcoming AIDS: the 'Next Agenda'.  // Report on the Global HIV/AIDS Epidemic: UNAIDS - 2004;1/1/2004, p11 

    Chapter 1 of the book "2004 Report on the global AIDS epidemic" is presented. It explores the agenda in the determination of the resources needed in the prevention of AIDS, care and to alleviate the impact. It highlights the factors that drive the epidemic, as well as the vulnerability and...

  • Reframing "Prevention with Positives": Incorporating Counseling Techniques That Improve the Health of HIV-Positive Patients. Gerbert, Barbara; Danley, Dale W.; Herzig, Karen; Clanon, Kathleen; Ciccarone, Daniel; Gilbert, Paul; Allerton, Michael // AIDS Patient Care & STDs;Jan2006, Vol. 20 Issue 1, p19 

    Federal HIV prevention strategy seeks to increase efforts by health care providers to identify and reduce their HIV-positive patients' transmission-related behaviors. Implementation of these recommendations will be hindered if providers perceive these efforts have the potential to harm their...

  • Use of Efavirenz Is Not Associated with a Higher Risk of Depressive Disorders: A Substudy of the Randomized Clinical Trial ALIZE-ANRS 099. Journot, Valérie; Chêne, Geneviève; De Castro, Nathalie; Rancinan, Corinne; Cassuto, Jill-Patrice; Allard, Christian; Vildé, Jean-Louis; Sobel, Alain; Garré, Michel; Molina, Jean-Michel // Clinical Infectious Diseases;6/15/2006, Vol. 42 Issue 12, p1790 

    Background. Efavirenz (EFV) is a highly active antiretroviral drug, use of which is associated with frequent (although transient) neurosensorial adverse reactions. Whether the use of EFV is associated with the risk of depression or suicide remains controversial. Methods. ALIZE-ANRS (Agence...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics