The Mycobacteria Story in Crohn's Disease

Shanahan, Fergus; O'Mahony, Jim
July 2005
American Journal of Gastroenterology;Jul2005, Vol. 100 Issue 7, p1537
Academic Journal
The heterogeneity of Crohn's disease suggests that it would be unwise to dismiss an infectious contribution to the pathogenesis in a subset of patients. The most enduring infectious candidate has been Mycobacterium paratuberculosis, which appears to be widespread in nature and appears to have the potential to infect humans. However, there are many counterarguments to the notion that MAP causes Crohn's disease, and numerous observations are seemingly at variance with this concept. (Am J Gastroenterol 2005;100;1537–1538)


Related Articles

  • Levamisole in Crohn's Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Sachar, David B.; Rubin, K. P.; Gumaste, Vivek // American Journal of Gastroenterology;Jun1987, Vol. 82 Issue 6, p536 

    To evaluate the efficacy of levamisole in the treatment of Crohn's disease, 19 patients were entered into a long-term, randomized, double-blind, placebo-controlled clinical trial. Seventeen patients (eight in the levamisole group and nine in the placebo group) completed the initial treatment arm...

  • Natalizumab.  // Reactions Weekly;6/25/2005, Issue 1057, p14 

    Discusses research being done on progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. Reference to a study by G. Van Assche et al published in the 2005 issue of the "New England Journal of Medicine"; Findings of the study.

  • Small bowel intussusception due to metastatic malignant melanoma. A case report. Gatsoulis, N.; Roukounakis, N.; Kafetzis, I.; Gasteratos, S.; Mavrakis, G. // Techniques in Coloproctology;Nov2004 Supplement 1, Vol. 8, ps141 

    Small bowel metastatic deposits attributed to malignant melanoma are found in 2-5% of patients with malignant melanoma of the skin. Ileo-ileo intussusception caused by metastatic melanoma is a very rare condition. The prognosis of metastatic melanoma is poor. We report a case of a cutaneous...

  • Metastatic Vulvar Ulceration in Crohn's Disease. Reyman, Lynn; Milano, Andrew; Demopoulos, Rita; Mayron, Jacob; Schuster, Steven // American Journal of Gastroenterology;Jan1986, Vol. 81 Issue 1, p46 

    Presents two cases of patients with vulvar ulcerations and Crohn's disease. Condition of the patients; Information on Crohn's disease; Treatment modalities of metastatic ulcers associated with Crohn's disease.

  • Sulfasalazine Pneumonitis. Yaffe, Bruce H.; Korelitz, Burton I. // American Journal of Gastroenterology;Aug1983, Vol. 78 Issue 8, p493 

    A man with alleged Crohn's disease of the terminal ileum was started on sulfasalazine. Five weeks later he developed progressive cough, shortness of breath, and fever associated with peripheral eosinophilia and bilateral pulmonary infiltrates. After withdrawal of sulfasalazine all abnormalities...

  • Free Perforation in Crohn's Disease: A Report of 33 Cases and Review of Literature. Katz, Seymour; Schulman, Nathan; Levin, Leroy // American Journal of Gastroenterology;Jan1986, Vol. 81 Issue 1, p38 

    Thirty-three patients with free perforation in Crohn's disease are described. There are 14 males and 19 females in this series with ages ranging from 14 to 79 years. The sites of perforation were 22 of the ileum, nine colonic, one jejunal, and one gastroduodenal. Toxic megacolon coexisted in...

  • A Controlled Trial Comparing Ciprofloxacin With Mesalazine for the Treatment of Active Crohn's Disease. Colombel, Jean-Frédéric; Lémann, Marc; Cassagnou, Michel; Bouhnik, Yoram; Duclos, Bernard; Dupas, Jean-Louis; Notteghem, Bertrand; Mary, Jean-Yves // American Journal of Gastroenterology;Mar1999, Vol. 94 Issue 3, p674 

    OBJECTIVE: The aim of this randomized controlled study was to investigate the efficacy of ciprofloxacin compared with mesalazine in treating active Crohn's disease. METHODS: Patients with a mild to moderate flare-up of Crohn's disease (mean Crohn's Disease Activity Index [CDAI]; 217; range,...

  • Crohn's disease with life-threatening hemorrhage from terminal ileum: successful control by superselective arterial embolization. Kazama, Yoshihiro; Watanabe, Toshiaki; Akahane, Masaaki; Yoshioka, Naoki; Ohtomo, Kuni; Nagawa, Hirokazu // Journal of Gastroenterology;Dec2005, Vol. 40 Issue 12, p1155 

    A case of life-threatening lower gastrointestinal hemorrhage from Crohn's disease is reported. Several promising studies have recently been published that describe superselective embolization for the treatment of massive lower gastrointestinal hemorrhage in patients with bleeding colonic...

  • Somatropin.  // Reactions Weekly;9/15/2007, Issue 1169, p25 

    The article describes the case of a woman with Crohn's disease who developed ileal perforation during treatment with somatropin. The patient received up to 1.04 mg/day of self-administered injections of somatropin from September 2002 to October 2003. She developed severe pain in her right lower...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics