Are we studying the correct state of the stellate cell to elucidate mechanisms of chronic pancreatitis?

Pandol, S. J.
June 2005
Gut;Jun2005, Vol. 54 Issue 6, p744
Academic Journal
The article discusses about important insights into the states of pancreatic stellate cells and their relation to the disease conditions of the pancreas. The processes of chronic pancreatitis include chronic inflammation and fibrosis with loss of parenchymal cells of the exocrine and endocrine pancreas. Studies with these cells suggest that they play a key role in chronic pancreatitis in a manner analogous to hepatic stellate cells and hepatic fibrosis. In common with liver fibrosis and hepatic stellate cells there is increasing evidence demonstrating a central role for pancreatic stellate cells (PSCs) in pancreatic fibrosis and chronic pancreatitis. In the normal pancreas, quiescent PSCs are identified using antibodies to desmin, a cytoskeletal protein and specific PSC marker.


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