TITLE

Review: Misoprostol or COX-2-specific or selective NSAIDs reduce gastrointestinal complications and symptomatic ulcers: COMMENTARY

AUTHOR(S)
Wong, Vincent W.S.; Chan, Francis K.L.
PUB. DATE
May 2005
SOURCE
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p75
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
This article reports that several important conclusions can be drawn from the study, which reported that misoprostol or COX-2-specific or selective non-steroidal anti-inflammatory drugs (NSAID) reduce gastrointestinal complications and symptomatic ulcers. First, although the investigators found that COX-2-selective NSAIDs reduced the risk for symptomatic ulcers and gastrointestinal symptoms, no reductions were seen in endoscopic ulcers and ulcer complications. This finding raises concerns that COX-2-selective NSAIDs might actually do more harm than good by masking dyspeptic symptoms and should be avoided in high-risk patients.
ACCESSION #
17116545

 

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