Circulating endothelial progenitor cells in pulmonary inflammation

Doerschuk, C. M.
May 2005
Thorax;May2005, Vol. 60 Issue 5, p362
Academic Journal
The article discusses the role played by endothelial progenitor cells (EPC) in lung repair. Many investigators have begun to address the ability of various populations of stem cells to aid in the repair of nearly every organ including the lungs, either through recruitment and differentiation into parenchymal cells or through facilitating proliferation and differentiation of cells already present to mediate the repair. Patients with pneumonia confined to one lobe and no other illnesses have circulating EPC in their blood within the first day of illness and that this number is decreased 8 weeks after treatment and recovery.


Related Articles

  • Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway. JIWEI LI; SHA HUANG; JUNHUA ZHANG; CHANGJIANG FENG; DONGYUN GAO; BIN YAO; XU WU; XIAOBING FU // Molecular Medicine Reports;2016, Vol. 13 Issue 5, p3755 

    Lung epithelium restoration subsequent to injury is of concern in association with the outcomes of diverse inflammatory lung diseases. Previous studies have demonstrated that mesenchymal stem cells (MSCs) may promote epithelial repair subsequent to inflammatory injury, however the mechanism that...

  • Streptococcus pneumoniae strain-dependent lung inflammatory responses in a murine model of pneumococcal pneumonia. Mohler, Jacqueline; Azoulay-Dupuis, Esther; Amory-Rivier, Cécile; Mazoit, Jean Xavier; Bédos, Jean Pierre P.; Rieux, Véronique; Moine, Pierre; Amory-Rivier, Cécile; Bédos, Jean Pierre P; Rieux, Véronique // Intensive Care Medicine;May2003, Vol. 29 Issue 5, p808 

    Objective: The inherent properties of an invading bacterium may influence the cytokine profile that is ultimately produced. We determined the alterations in proinflammatory (TNF-alpha, IL-1, and IL-6) and anti-inflammatory cytokine (IL-10) expressions in lung tissues within the...

  • Characterization of lymphocyte populations in nonspecific interstitial pneumonia. Keogh, Karina A.; Limper, Andrew H. // Respiratory Research;2005, Vol. 6, p137 

    Study objectives: Nonspecific interstitial pneumonia (NSIP) has been identified as a distinct entity with a more favorable prognosis and better response to immunosuppressive therapies than usual interstitial pneumonia (UIP). However the inflammatory profile of NSIP has not been characterized....

  • Respiratory Disorders.  // Current Medical Literature: Pediatrics;2006, Vol. 19 Issue 1, p24 

    Presents the abstract of several studies on respiratory disorders in children. "Successful Hematopoietic Stem Cell Transplantation for Niemann-Pick Disease Type B"; "Genetic Modifiers of Lung Disease in Cystic Fibrosis"; "Neurological and Neuromuscular Disease as a Risk Factor for Respiratory...

  • RNA-Seq quantification of the human small airway epithelium transcriptome.  // BMC Genomics;2012, Vol. 13 Issue 1, p82 

    The article presents a study which aims at a quantitative assessment of small airway epithelium (SAE) transcriptome. It informs that the SAE cell population is a major site of lung diseases caused by smoking and explains the methodology of the study, in which parallel mRNA sequencing (RNA-Seq)...

  • Raised protein levels and altered cellular expression of factor VII activating protease (FSAP) in the lungs of patients with acute respiratory distress syndrome (ARDS). Wygrecka, Malgorzata; Markart, Philipp; Fink, Ludger; Guenther, Andreas; Preissner, Klaus T. // Thorax;Oct2007, Vol. 62 Issue 10, p880 

    Background: The acute respiratory distress syndrome (ARDS) is characterised by inflammation of the lung parenchyma and changes in alveolar haemostasis with extravascular fibrin deposition. Factor VII activating protease (FSAP) is a recently described serine protease in plasma and tissues known...

  • Irreversible long-term pulmonary functional impairments after adenovirus type-7 pneumonia: assessment with xenon-133 ventilation and Tc-99-m MAA perfusion studies. Suga, K.; Ishikawa, Y.; Motoyama, K.; Kume, N.; Matsunaga, N. // European Radiology;Sep2000, Vol. 10 Issue 9, p1411 

    A 3-year-old child presented with severe type-7 adenoviral pneumonia, after the resolution of diffuse pulmonary infiltrates of the pneumonia. Xenon-133 ventilation and Tc-99-m macroaggregated albumin (MAA) perfusion studies revealed a localized airflow obstruction and matched perfusion defect,...

  • Actinobacillosis as cause of pneumonia in a goat. Shahbazfar, Amir Ali; Tavasoli, Abbas // Comparative Clinical Pathology;Nov2010, Vol. 19 Issue 4, p417 

    A 3-year-old female goat was referred to the veterinary hospital of Tehran University with a history of respiratory problems, emaciation, and poor body condition. At necropsy, the lungs were heavier than normal and showed grayish sulfur granules. The pleura had adhesion to the thoracic wall with...

  • Clinical and therapeutic aspects of childhood kerosene poisoning in Djibouti. Benois, Alain; Petitjeans, Fabrice; Raynaud, Laurent; Dardare, Eric; Sergent, Hervé // Tropical Doctor;Oct2008, Vol. 39 Issue 4, p236 

    We report a prospective and descriptive study about childhood acute poisoning with kerosene in Djibouti. Acute poisoning is a common and stable occurrence in low socioeconomic groups in Africa, where negligence is the main cause of poisoning. The respiratory system was the main target, with 41%...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics