Autoimmune pancreatitis -- also a Western disease

Suffon, R
May 2005
Gut;May2005, Vol. 54 Issue 5, p581
Academic Journal
The article focuses on autoimmune pancreatitis. Autoimmune pancreatitis is recognized worldwide as a T cell mediated, organ specific disease characterized by lymphocytic infiltration of the exocrine parenchyma with fibrosis and autoantibodies, including to carbonic anhydrase II. Spontaneous development of autoimmune pancreatitis is a characteristic of the autoimmune disease prone MRL/+ mouse and Wistar Bonn/Kobori rat, and also occurs in German shepherd and rough coated collie dogs.


Related Articles

  • Response to self antigen imprints regulatory memory in tissues. Rosenblum, Michael D.; Gratz, Iris K.; Paw, Jonathan S.; Lee, Karen; Marshak-Rothstein, Ann; Abbas, Abul K. // Nature;12/22/2011, Vol. 480 Issue 7378, p538 

    Immune homeostasis in tissues is achieved through a delicate balance between pathogenic T-cell responses directed at tissue-specific antigens and the ability of the tissue to inhibit these responses. The mechanisms by which tissues and the immune system communicate to establish and maintain...

  • Autoimmunity: Targeted TRegs tame autoimmune disease. Flemming, Alexandra // Nature Reviews Drug Discovery;Jan2010, Vol. 9 Issue 1, p19 

    The article presents research on the association of regulatory T cells (T Regs ) to autoimmune disease. It notes that these cells can tame their inflammatory counterparts. Study shows suppression despite the recognition of distinct antigens by regulatory and pathologenic T cells. This indicates...

  • Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. Niki, Shino; Oshikawa, Kiyotaka; Mouri, Yasuhiro; Hirota, Fumiko; Matsushima, Akemi; Yano, Masashi; Han, Hongwei; Bando, Yoshimi; Izumi, Keisuke; Matsumoto, Masaki; Nakayama, Keiichi I.; Kuroda, Noriyuki; Matsumoto, Mitsuru // Journal of Clinical Investigation;May2006, Vol. 116 Issue 5, p1292 

    Factors that determine the spectrum of target organs involved in autoimmune destruction are poorly understood. Although loss of function of autoimmune regulator (AIRE) in thymic epithelial cells is responsible for autoimmunity, the pathogenic roles of AIRE in regulating target-organ specificity...

  • Organ-Specific Autoimmunity. Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p492 

    A definition of the term "organ-specific autoimmunity" is presented. It refers to autoimmune disease that affects a single organ in the body such as the pancreas in type 1 diabetes

  • Autoimmune Pancreatitis: An Autoimmune or Immunoinflammatory Disease? Hsieh, Yvonne; Agrawal, Sudhanshu; Yel, Leman; Gupta, Sudhir // Open Autoimmunity Journal;2011, Vol. 3, p10 

    Autoimmune pancreatitis (AIP) has been widely presumed to be an autoimmune disease that is characterized by elevated IgG and/or IgG4, the presence of autoantibodies, and an infiltration of lymphocytes and plasma cells with fibrosis. However, no detailed immunological studies have been published....

  • Pathologic Findings of Autoimmune Pancreatitis and IgG4-Related Disease. Notohara, Kenji; Wani, Yoji; Fujisawa, Masayoshi // Current Immunology Reviews;May2011, Vol. 7 Issue 2, p212 

    Autoimmune pancreatitis (AIP) is pathologically characterized by lymphoplasmacytic infiltration and fibrosis. However, AIP is not a single entity, but rather includes two histological types--lymphoplasmacytic sclerosing pancreatitis (LPSP) and idiopathic duct-centric chronic pancreatitis...

  • Imaging: Early detection for pancreatic cancer. Goymer, Patrick // Nature Reviews Cancer;Jun2008, Vol. 8 Issue 6, p408 

    The article discusses a research that has identified a biomarker, which when conjugated to a nanoparticles, enable detection of early-stage pancreatic cancer. It relates the authors of the research used a phage display approach in mouse model to screen for peptides that specifically bind to cell...

  • Knowing one's self: central tolerance revisited. Sprent, Jonathan; Surh, Charles D. // Nature Immunology;Apr2003, Vol. 4 Issue 4, p303 

    Focuses on the tolerance induction of the T cells to tissue specific antigens (TSAs) in the thymus. Concept of central tolerance; Gene that controls the expression of TSAs in the thymus medulla; Explanation for the effect of antigens on the immune system; Lack of information regarding the gene...

  • Immunological Aspects of IgG4-Related Disease. Okazaki, Kazuichi; Uchida, Kazushige // Current Immunology Reviews;May2011, Vol. 7 Issue 2, p204 

    Recent advances support the concept of IgG4-related disease as a unique systemic disease, because autoimmune pancreatitis, sclerosing cholangitis, sclerosing sialadenitis, retroperitoneal fibrosis show similar pathological features with an abundant infiltration of IgG4 positive plasma cells and...


Read the Article


Sign out of this library

Other Topics