Is big beautiful? The continuing story of ADAM33 and asthma

Holgate, S. T.; Holloway, J. W.
April 2005
Thorax;Apr2005, Vol. 60 Issue 4, p263
Academic Journal
The article reports that the gene encoding A Disintegrin And Metalloprotease (ADAM) 33 was the first asthma susceptibility gene to be discovered by positional cloning. In 460 families enriched with asthma, linkage analysis using micro-satellite markers spaced 9 cM apart revealed a region on chromosome 20p13 that carried one or more asthma genes, achieving a Maximum Lod Score (MLS) of 2.24 at 9.99 cM. Several features of this initial report raised questions regarding the generalizability of the results.


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