Transglutaminases: new target molecules for inflammatory bowel disease?

Siegmund, B.; Zeitz, M.
April 2005
Gut;Apr2005, Vol. 54 Issue 4, p443
Academic Journal
This article presents information on transglutarninases. The family of transglutaminases (TG) includes the plasma form factor XIIIa as well as the tissue transglutaminase (tTG) and keratinocyte transglutaminase (TGk). In particular, tTG reminds every gastroenterologist primarily of coeliac disease where tTG represents the key autoantigen. These bonds are formed between glutaminase and lysinc residues thus stabilizing intra- and extracellular proteins, a process which is required for a variety of essential physiological purposes such as barrier function in epithelia, apoptosis, and extracellular matrix formation.


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