TITLE

Muscling into cystic Fibrosis airways

AUTHOR(S)
Sutcliffe, A. M.; Knox, A. J.
PUB. DATE
March 2005
SOURCE
Thorax;Mar2005, Vol. 60 Issue 3, p181
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
The article focuses on cystic fibrosis that develop progressive airflow obstruction. Pathological studies of the lungs of patients obtained either at necropsy or transplantation or lobectomy showed an increase in smooth muscle area compared with healthy controls or patients with chronic obstructive pulmonary disease. The volume of smooth muscle in the airway submucosa in subjects with cystic fibrosis was higher than in normal controls. Airway inflammation and remodelling involves not just inflammatory cells but also structural cells such as fibroblasts, epithelial cells and airway smooth muscle cells.
ACCESSION #
16455981

 

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