TITLE

EDITOR'S QUIZ: GI SNAPSHOTS

PUB. DATE
January 2005
SOURCE
Gut;Jan2005, Vol. 54 Issue 1, p174
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
This article reports that the computed tomography scan shows a marked decreased in pancreatic volume compared with the scan performed before bone marrow transplantation (BMT), the pancreas appearing as a thin band of tissue. Pancreatic enzymes were administered and allowed normalisation of intestinal transit and an increase in body weight. Even if the contribution of intestinal graft versus host disease (GVHD) cannot be ruled out in our patient, the most plausible explanation for her diarrhea was that is was pancreatic in origin. The rapid development of pancreatic atrophy in the context of GVHD strongly suggests that this disease contributed to pancreatic destruction as well as to the fact that pancreatic insufficiency developed after the decrease in immunosuppression. Exocrine pancreatic insufficiency after BMT has been reported previously, and in an autopsy study of 15 children who died after a BMT, a case of pancreatic atrophy was found, with extensive interstitial fibrosis and mild inflammation.
ACCESSION #
16163252

 

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