aHIF: The missing link between HIF-1 and VHL?
Tags: ANOXEMIA; TRANSCRIPTION factors
Related Articles
- Is HIF-1a a Valid Therapeutic Target? Pili, Roberto; Donehower, Ross C. // JNCI: Journal of the National Cancer Institute;4/2/2003, Vol. 95 Issue 7, p498
No abstract available.
- Hypoxia inducible factor 1a and 2a overexpression in inflammatory bowel disease. Giatromanolaki, A.; Sivridis, E.; Maltezos, E.; Papazoglou, D.; Simopoulos, C.; Gatter, K.C.; Harris, A.L.; Koukourakis, M.I. // Journal of Clinical Pathology;Mar2003, Vol. 56 Issue 3, p209
Aims: Hypoxia inducible factors 1a and 2a (HIF1a and HIF2a) are hypoxia regulated transcriptional factors, which control the expression of a variety of genes responsible for angiogenesis, glycolysis, and the inhibition of apoptosis. Because angiogenesis and tissue regeneration are integral...
- Hypoxia Inducible Factor as a Cancer Drug Target. Welsh, Sarah J.; Powis, Garth // Current Cancer Drug Targets;Dec2003, Vol. 3 Issue 6, p391
Solid tumors with areas of hypoxia are the most aggressive and difficult tumors to treat and are a major reason for treatment failure. Previous attempts to treat hypoxic tumors have been largely unsuccessful and new agents are needed. The cellular response to hypoxia is controlled by the hypoxia...
- Targeting tumors through the HIF system. Ratcliffe, Peter J.; Pugh, Christopher W.; Maxwell, Patrick H. // Nature Medicine;Dec2000, Vol. 6 Issue 12, p1315
Reports on a method developed by researcher A.L. Kung, et al, to block the co-activation of the alpha subunit of hypoxia-inducible factor (HIF), a key transcriptional regulator of the cellular response to hypoxia that is upregulated in common cancers. Characteristics of HIF; Significance of the...
- Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression. Hirota, Kiichi // Journal of Anesthesia;2002, Vol. 16 Issue 2, p150
Focuses on responses to subacute or chronic hypoxia that involve changes in gene expression that are mediated by the transcriptional regulator hypoxia-inducible factor 1 (HIF-1). Molecular biology of HIF-1; Involvement of HIF-1 in physiological and pathophysiological processes; Summary and...
- Hypoxia-inducible transcription factor-1a promotes hypoxia-induced A549 apoptosis via a mechanism that involves the glycolysis pathway. FengMing Luo; XiaoJing Liu; NaiHong Yan; ShuangQing Li; GuiQun Cao; QingYing Cheng; QingJie Xia; HongJing Wang // BMC Cancer;2006, Vol. 6, p26
Background: Hypoxia-inducible transcription factor-1a (HIF-1a), which plays an important role in controlling the hypoxia-induced glycolysis pathway, is a "master" gene in the tissue hypoxia response during tumor development. However, its role in the apoptosis of non-small cell lung cancer...
- Hypoxia inducible factor-1: regulation by nitric oxide in posthypoxic microvascular endothelium. Natarajan, Ramesh; Jones, Drew G.; Fisher, Bernard J.; Wallace, Timothy J.; Ghosh, Shobha; Fowler III, Alpha A. // Biochemistry & Cell Biology;Oct2005, Vol. 83 Issue 5, p597
Microvascular endothelial cells provide a critical regulatory interface between blood constituents and tissue. Hypoxia inducible factor-1 (HIF-1) is a key transcription factor required for expression of hypoxia-dependent genes. We employed a model of hypoxia and reoxygenation (H/R) using the...
- Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. Cangul, Hakan // BMC Genetics;2004, Vol. 5, p1
Background: The expression of NDRG1 gene is induced by nickel, a transition metal sharing similar physical properties to cobalt. Nickel may create hypoxia-like conditions in cells and induce hypoxia-responsive genes, as does cobalt. Therefore NDRG1 is likely to be another gene induced by...
- Contribuci�n de la hipoxia en la remodelaci�n del tejido pulmonar en procesos asm�ticos. J. Baay Guzm�n, Guillermina; Hern�ndez Cueto, �ngeles; Huerta Yepez, Sara // Revista Alergia de Mexico;ene/feb2008, Vol. 55 Issue 1, p18
Asthma is a chronic airway inflammatory disease that is associated with pulmonary remodelling of respiratory tissue. During asthma, lung structure changes due to persistent inflammation and causes obstruction of the air flow, which leads to a paradoxical hypoxic condition in the affected...
