Environment allergen exposure, sensitisation and asthma: from whole populations to individuals at risk

Custovic, A.; Simpson, A.
October 2004
Thorax;Oct2004, Vol. 59 Issue 10, p825
Academic Journal
This article presents information on methods used to prevent asthma and allergy. Sensitisation to inhalant allergens remains a major risk factor for asthma, but the size of the effect is hotly debated. Several observational birth cohort studies investigating risk factors for the development of allergen sensitisation and asthma have measured allergen levels in dust samples collected in early life to examine the association between allergen exposure and the development of specific sensitisation. Some studies in older children and adults reported a close relationship between specific allergen sensitisation and current domestic exposure for mite and cockroach, but not cat allergen. A study called Isle of Wight Study implemented an intervention designed to reduce exposure to inhalant and food allergens as part of a primary prevention programme. Manchester Asthma and Allergy Study used a much more stringent environmental control regime than other primary prevention studies. A significant and sustained reduction in allergen exposure was achieved in the active group.


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