TITLE

Pi MZ and COPD: will we ever know?

AUTHOR(S)
Seershoim, N.
PUB. DATE
October 2004
SOURCE
Thorax;Oct2004, Vol. 59 Issue 10, p823
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
This article reports that there is no reason to believe that individuals of genotype Pi MZ have an increased risk of developing lung disease as long as they do not smoke. A very high percentage of patients with chronic obstructive pulmonary disease (COPD) have been smokers, but not all smokers develop COPD. There are a number of reasons for the discrepancy between the studies conducted on this subject. Firstly, smoking is a very significant confounder in the development of emphysema which is almost impossible to control for. Secondly, many studies have been subject to various types of bias, particularly selection bias. In case-control studies the researchers identify a group with COPD, find a proper control group without the disease, and compare the prevalence of the Pi MZ genotype between the two groups. A cohort study compares either the prevalence of COPD in a cross sectional setting or the incidence of COPD in a longitudinal setting of a group of Pi MZ individuals with a matched control group which can be derived from the general population.
ACCESSION #
14882948

 

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