Location location, location: microlocalisation of inflammatory cells and airways dysfunction

Brightling, C. E.; Pavord, I. D.
September 2004
Thorax;Sep2004, Vol. 59 Issue 9, p734
Academic Journal
The article focuses on the role of microlocalisation of inflammatory and structural cells in the pathogenesis of asthma, chronic obstructive pulmonary diseases (COPD) and cough. Activation of the inflammatory cells within the airway smooth muscle bundle would be predicted to have important consequences on airway smooth muscle function. The recognition of the importance of microlocalisation is not confined to inflammatory cells and airway smooth muscle cells, but is probably equally critical in interactions with other structural cells such as the epithelium, fibroblasts, mucosal glands, and nerve cells.


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