TRPV1 and cough

Anderson, G. P.
September 2004
Thorax;Sep2004, Vol. 59 Issue 9, p730
Academic Journal
The article emphasizes on the role of an ion channel called transient receptor potential vanilloid-1 (TRPV1) as a remedial development in cough. It has been known from electrophysiological studies that irritants such as citric acid and capsaicin activate respiratory tract sensory fibres, especially unmyelinated C fibres to discharge information via the vagus to the medullary cough centre. It was inferred that the cough receptor on sensory fibres might be an ion channel able to rapidly depolarize afferent nerve membranes and hence trigger cough inducing impulses.


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