TITLE

Antiviral agents and corticosteroids in the treatment of severe acute respiratory syndrome (SARS)

AUTHOR(S)
Yu, W. C.; Hui, D. S. C.; Chan-Yeung, M.
PUB. DATE
August 2004
SOURCE
Thorax;Aug2004, Vol. 59 Issue 8, p643
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
The epidemic of severe acute respiratory syndrome (SARS) of 2003 caught the medical profession by surprise. The accumulated global total caught the medical profession by number of cases was 8098 with 774 deaths, a case-fatality ratio of 9.6%. Although the novel coronavirus was discovered within weeks, treatment was inevitably empirical as controlled clinical trials were not possible during the epidemic of this new and serious illness.
ACCESSION #
14197037

 

Related Articles

  • SARS: Understanding the Virus and Development of Rational Therapy. Stadler, K.; Rappuoli, R. // Current Molecular Medicine;Nov2005, Vol. 5 Issue 7, p677 

    In late 2002 a new disease, severe atypical respiratory syndrome (SARS), emerged in China. A hitherto unknown animal coronavirus (CoV) that had crossed the species barrier through close contact of humans with infected animals was identified as the etiological agent. It rapidly adapted to the new...

  • Integrating Newly Discovered Anti-Viral Herbs with Classical Wen Bing Theory. Fratkin, Jake // Oriental Medicine;2005, p418 

    Several charts on the classical Wen Bing theory and the response of traditional Chinese medicine to the SARS epidemic, 2003 are presented.

  • Identification of Residues of SARS-CoV nsp1 That Differentially Affect Inhibition of Gene Expression and Antiviral Signaling. Jauregui, Andrew R.; Savalia, Dhruti; Lowry, Virginia K.; Farrell, Cara M.; Wathelet, Marc G. // PLoS ONE;Apr2013, Vol. 8 Issue 4, p1 

    An epidemic of Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus-...

  • A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice. Roberts, Anjeanette; Deming, Damon; Paddock, Christopher D.; Cheng, Aaron; Yount, Boyd; Vogel, Leatrice; Herman, Brian D.; Sheahan, Tim; Heise, Mark; Genrich, Gillian L.; Zaki, Sherif R.; Baric, Ralph; Subbarao, Kanta // PLoS Pathogens;Jan2007, Vol. 3 Issue 1, p23 

    No single animal model for severe acute respiratory syndrome (SARS) reproduces all aspects of the human disease. Young inbred mice support SARS-coronavirus (SARS-CoV) replication in the respiratory tract and are available in sufficient numbers for statistical evaluation. They are relatively...

  • Antiviral treatment of SARS: Can we draw any conclusions? Zhaori, Getu // CMAJ: Canadian Medical Association Journal;11/25/2003, Vol. 169 Issue 11, p1165 

    Presents opinion on the antiviral therapy of severe acute respiratory syndrome (SARS). Experience with empirical treatment of SARS with ribavirin; Regimens that could be used or another outbreak of SARS.

  • Critically Ill Patients With Severe Acute Respiratory Syndrome. Fowler, Robert A.; Lapinsky, Stephen E.; Hallett, David; Detsky, Allan S.; Sibbald, William J.; Slutsky, Arthur S.; Stewart, Thomas E. // JAMA: Journal of the American Medical Association;7/16/2003, Vol. 290 Issue 3, p367 

    Context: Severe acute respiratory syndrome (SARS) is a newly recognized infectious disease capable of causing severe respiratory failure. Objective: To determine the epidemiological features, course, and outcomes of patients with SARS-related critical illness. Design, Setting, and Patients:...

  • How did general practitioners protect themselves, their family, and staff during the SARS epidemic in Hong Kong? Wong W C W; Lee A; Tsang K K; Wong S Y S // Journal of Epidemiology & Community Health;Mar2004, Vol. 58 Issue 3, p180 

    CONTEXT: Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease and how the frontline community doctors respond to it is not known. OBJECTIVES: To explore the impact of SARS on general practitioners (GPs) in Hong Kong. DESIGN: A cross sectional survey. SETTING: Community...

  • Interferon-β 1a and SARS Coronavirus Replication. Hensley, Lisa E.; Fritz, Elizabeth A.; Jahrling, Peter B.; Karp, Christopher L.; Huggins, John W.; Geisbert, Thomas W. // Emerging Infectious Diseases;Feb2004, Vol. 10 Issue 2, p317 

    A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive...

  • Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV--Infected Macaques. De Lang, Anna; Baas, Tracey; Teal, Thomas; Leijten, Lonneke M.; Rain, Brandon; Osterhaus, Albert D.; Haagmans, Bart L.; Katze, Michael G. // PLoS Pathogens;Aug2007, Vol. 3 Issue 8, p1129 

    The pathogenesis of severe acute respiratory syndrome coronavirus (SARS-CoV) is likely mediated by disproportional immune responses and the ability of the virus to circumvent innate immunity. Using functional genomics, we analyzed early host responses to SARS-CoV infection in the lungs of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics