TITLE

Regulation: the art of control? Regulatory T cells and asthma and allergy

AUTHOR(S)
Robinson, D. S.
PUB. DATE
August 2004
SOURCE
Thorax;Aug2004, Vol. 59 Issue 8, p640
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
Asthma is widely recognized as an inflammatory airway disease driven by activation of Th2-type T lymphocytes in both atopic allergic and intrinsic or non-allergic forms. Recent advances in author understanding of the control of the immunological process have identified regulatory suppressive T cells which can prevent activation of self-reactive or pathological T cells in autoimmune or infectious disease models. CD4+CD25+ T cells do not proliferate in vitro in many systems, it has recently been shown that human cells can be expanded in response to antigen and CD4+CD25+ T cells do proliferate upon in vivo transfer to mice.
ACCESSION #
14197036

 

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