TITLE

Rifampin and Pyrazinamide for Latent Tuberculosis Infection: Clinical Trials and General Practice

AUTHOR(S)
Saukkonen, Jussi
PUB. DATE
August 2004
SOURCE
Clinical Infectious Diseases;8/15/2004, Vol. 39 Issue 4, p566
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
The article focuses on the use of rifampin and pyrazinamide for the treatment of latent tuberculosis infection (LTBI). As the prevalence of active tuberculosis decreases in the U.S., the focus on treatment of LTBI has intensified. One of these LTBI regimens, a 2-month course of rifampin with pyrazinamide (RZ), has achieved considerable controversy because of serious concerns about its safety. The ensuing experience with RZ in the HIV-uninfected population raised serious concerns regarding the hepatotoxicity of the regimen. Researchers have found that individuals treated with a 2-month course of RZ developed significantly more elevations in the alanine aminotransferase level of grade ill or higher, compared with patients who were treated with a 6-months course of isoniazid, and RZ recipients were not more likely to complete the regimen.
ACCESSION #
14048110

 

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