Tumor Necrosis Factor Blockers and Reactivation of Latent Tuberculosis

Keane, Joseph
August 2004
Clinical Infectious Diseases;8/1/2004, Vol. 39 Issue 3, p300
Academic Journal
It is informed that patients with rheumatoid arthritis may be at increased risk of reactivation of infectious diseases that normally remain latent in granuloma. It is opined that this reactivation may occur because of immunosuppressive treatments, such as steroids or monoclonal anti-tumor necrosis factor antibodies (mAb). It is further informed that tumor necrosis factor (TNF) blockers have been in use for quite some time now and the reactivation of tuberculosis may occur less often with soluble TNF-receptor blocker than with mAb TNF blockers.


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