Mixed Glycoprotein B Genotypes of Cytomegalovirus and Immunosuppression

Crumpacker, Clyde S.
July 2004
Clinical Infectious Diseases;7/15/2004, Vol. 39 Issue 2, p162
Academic Journal
This article presents a commentary note on an article discussing mixed cytomegalovirus (CMV) glycoprotein B genotypes in immunocompromised patients. It is reported that CMV infection remains the most significant infection affecting the outcome of solid-organ transplantation or hematopoietic stem cell transplantation. The remarkable achievements associated with antiviral therapy for CMV infection have led to the development of 2 new challenges in transplant recipients: the new syndrome of late-onset CMV disease, and infection with drug-resistant strains of CMV. But, late-onset CMV disease syndrome is analyzed to be the result of antiviral therapy delaying but not preventing the onset of CMV disease in patients who are predisposed to develop it. Antiviral prophylaxis has also been attributed to improvement in events indirectly associated with CMV infection, such as decreases in the rate of graft rejection and improvements in the use of in-patient medical resources.


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