Monitoring mast cell activation by prostaglandin D2 in vivo

Dahlén, S.-E.; Kumlin, M.
June 2004
Thorax;Jun2004, Vol. 59 Issue 6, p453
Academic Journal
While the pro-inflammatory role of eosinophilic granulocytes in asthma is currently under debate, an increasing body of evidence suggests that mast cells may indeed orchestrate many of the characteristic pathophysiological changes in asthma. There are also indications that the mast cell may be an effector cell in other lung diseases such as chronic obstructive pulmonary disease and lung fibrosis. Given the location of mast cells at multiple sites within the airways, they clearly have the potential to function as sensors of alterations in the microenvironment-be it to inhaled or bloodborne substances, microbes, or other insults that require a prompt host defense reaction.


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