Antibiotic Use and the Risk of Pneumonia: 20 Years of Studies, but Where Are We Now?

Diaz, Emili; Rello, Jordi; Valles, Jordi
May 2004
Clinical Infectious Diseases;5/15/2004, Vol. 38 Issue 10, p1409
Academic Journal
The article examines the use of antibiotics and the risk of ventilator-associated pneumonia. The majority of antibiotics used in the ICUs are active against the normal oropharyngeal flora. Antibiotic use was useful as preemptive therapy for early-onset pneumonia in patients who were admitted to the hospital with coma, but it was associated with an increase in pneumonia due to antibiotic-resistant microorganisms in patients admitted because of trauma. Although antibiotic exposure may reduce the rate of early-onset pneumonia, researchers need to look forward and to assess the effect of antibiotics on delayed nosocomial infection and length of stay, and mortality rate.


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