Vessels: new targets for asthma treatment

Wilson, J. W.; Li, X.
December 2001
Thorax;Dec2001, Vol. 56 Issue 12, p899
Academic Journal
This article focuses on the significance of airway vessels in asthma. This has become more relevant since the finding of increased vessel numbers and vascularity in the submucosa of patients with relatively mild asthma. The description of asthmatic bronchial vessels has been extended beyond traditional views of vessel function. As well as supplying nutrients to the vessel wall, temperature regulation, and facilitating humidification of the airway environment, vessels have several other important functions in the asthmatic response that may contribute to airflow obstruction. Firstly, angiogenesis has been described in airway sections, identifying more vessels in asthma when anti-collagen IV antibodies were used to detect vascular basement membrane. Vessel numbers are predominantly regulated by factor dependent endothelial cell proliferation.


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