TITLE

Macrolide antibiotics and cystic Fibrosis

AUTHOR(S)
Peckham, D. G.
PUB. DATE
March 2002
SOURCE
Thorax;Mar2002, Vol. 57 Issue 3, p189
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
There is growing interest in the potential use of macrolide antibiotics as anti-inflammatory agents in cystic fibrosis. This stems from the dramatic success of long term erythromycin in the treatment of diffuse panbronchiolitis (DPB), a condition with a high prevalence in Japan but rare elsewhere. Clinically, DPB exhibits some similarities to cystic fibrosis including chronic productive cough, exertional dyspnoea, chronic sinusitis, mucoid Pseudomonas aeruginosa colonisation and bronchiectasis. The introduction of erythromycin as a treatment for DPB has had a dramatic impact on mortality.
ACCESSION #
12915246

 

Related Articles

  • Clinical Implications of Macrolide Therapy in Chronic Sinopulmonary Diseases. Martinez, Fernando J.; Simon, Richard H. // Current Pharmaceutical Design;Oct2004, Vol. 10 Issue 25, p3095 

    Macrolides have broad antibacterial spectrum and proven efficacy in the management of respiratory tract infections. Over the past decade there has been progressive interest in these agents for their potential role as tissue modifying, anti-inflammatory agents. Increasingly, the effect of...

  • Directed neutrophil migration to IL-8 is increased in cystic fibrosis: a study of the effect of erythromycin. Brennan, S.; Cooper, D.; Sly, P. D. // Thorax;Jan2001, Vol. 56 Issue 1, p62 

    Background -- The aim of this study was to compare neutrophil migration in cystic fibrosis (CF) and non-CF populations and to investigate the effect of erythromycin on directed migration of neutrophils (PMNs) in CE Methods -- PMNs were isolated and their migratory capacity in response to...

  • Serendipity of Erythromycin in the Management of Periprosthetic Inflammation. Ren, Weiping; Blasier, Ralph; Markel, David C. // Current Drug Therapy;May2011, Vol. 6 Issue 2, p113 

    The formation of an inflammatory periprosthetic membrane at the interface of the bone and the prosthesis constitutes a major component of periprosthetic osteolysis and aseptic loosening (AL). Prevention and treatment of periprosthetic membrane inflammation represent a logical approach to prevent...

  • Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. Zarogoulidis, P.; Papanas, N.; Kioumis, I.; Chatzaki, E.; Maltezos, E.; Zarogoulidis, K. // European Journal of Clinical Pharmacology;May2012, Vol. 68 Issue 5, p479 

    Background: Macrolides have long been recognised to exert immunomodulary and anti-inflammatory actions. They are able to suppress the 'cytokine storm' of inflammation and to confer an additional clinical benefit through their immunomodulatory properties. Methods: A search of electronic journal...

  • Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: a randomised trial. Wolter, J.; Seeney, S.; Bell, S.; Bowler, S.; Masel, P.; McCormack, J. // Thorax;Mar2002, Vol. 57 Issue 3, p212 

    Background: Relentless chronic pulmonary inflammation is the major contributor to morbidity and mortality in patients with cystic fibrosis (CF). While immunomodulating therapies such as prednisolone and ibuprofen may be beneficial, their use is limited by side effects. Macrolides have...

  • Sdz Asm 981. Wellington, K.; Spencer, C.M. // BioDrugs;2000, Vol. 14 Issue 6, p409 

    â–´ SDZ ASM 981 is an anti-inflammatory macrolactam which binds with high affinity to macrophilin-12. The resulting complex inhibits calcineurin, thus blocking the synthesis of inflammatory cytokines. â–´ Twice daily application of topical SDZ ASM 981 1% cream was effective in the...

  • Highlights of Semi-synthetic Developments from Erythromycin A. Yon-Jin Wu, Marc A. // Current Pharmaceutical Design;Jan2000, Vol. 6 Issue 2, p181 

    Earlier semi-synthetic studies of erythromycin A culminated in the discovery of two successful second generation macrolide antibiotics, azithromycin and clarithromycin, for the treatment of community-acquired bacterial infections. More recent structural modifications of erythromycin A have...

  • Macrocycles in Medicinal Chemistry and Drug Discovery. Oyelere, Adegboyega K. // Current Topics in Medicinal Chemistry;Oct2010, Vol. 10 Issue 14, p1359 

    An introduction to the articles discussed within the issue is presented, including an article on the chemoinformatic strategies for the analysis of bioactive macrocycles, another article on the susceptibility of macrocyclic templates derived from 14- and 15-membered macrolides to selective...

  • Molecular mechanisms of resistance to antibiotics in Bartonella bacilliformis. Silpak Biswas; Didier Raoult; Jean-Marc Rolain // Journal of Antimicrobial Chemotherapy (JAC);Jun2007, Vol. 59 Issue 6, p1065 

    : Objectives Bartonella bacilliformis is the aetiological agent of Carrions disease. Although ciprofloxacin, rifampicin and erythromycin have been successfully used in the treatment of the disease, failures and relapses have been reported. The objective of our study was to select in vitro...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics