Macrolide antibiotics and cystic Fibrosis

Peckham, D. G.
March 2002
Thorax;Mar2002, Vol. 57 Issue 3, p189
Academic Journal
There is growing interest in the potential use of macrolide antibiotics as anti-inflammatory agents in cystic fibrosis. This stems from the dramatic success of long term erythromycin in the treatment of diffuse panbronchiolitis (DPB), a condition with a high prevalence in Japan but rare elsewhere. Clinically, DPB exhibits some similarities to cystic fibrosis including chronic productive cough, exertional dyspnoea, chronic sinusitis, mucoid Pseudomonas aeruginosa colonisation and bronchiectasis. The introduction of erythromycin as a treatment for DPB has had a dramatic impact on mortality.


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