The labyrinth of asthma phenotypes and exhaled NO

Baraldi, E.; Zanconato, S.
May 2001
Thorax;May2001, Vol. 56 Issue 5, p333
Academic Journal
In the May 1, 2001 issue of the journal "Thorax," researchers suggest that it is possible to distinguish different patterns of difficult childhood asthma by measuring exhaled nitrogen oxide (NO). The knowledge that severe asthma may have different phenotypes with different types of airway inflammation is not new and has been clearly shown by bronchoalveolar lavage and airway biopsy studies in adult patients. The potential importance of these data lies in the classification of different patterns by using a non-invasive instantaneous measurement such as NO. Exhaled NO levels are known to be increased in atopic asthma, to increase during an exacerbation, to decrease with anti-inflammatory therapy, and to rise as the dose of inhaled steroids is reduced.


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