TITLE

The labyrinth of asthma phenotypes and exhaled NO

AUTHOR(S)
Baraldi, E.; Zanconato, S.
PUB. DATE
May 2001
SOURCE
Thorax;May2001, Vol. 56 Issue 5, p333
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
In the May 1, 2001 issue of the journal "Thorax," researchers suggest that it is possible to distinguish different patterns of difficult childhood asthma by measuring exhaled nitrogen oxide (NO). The knowledge that severe asthma may have different phenotypes with different types of airway inflammation is not new and has been clearly shown by bronchoalveolar lavage and airway biopsy studies in adult patients. The potential importance of these data lies in the classification of different patterns by using a non-invasive instantaneous measurement such as NO. Exhaled NO levels are known to be increased in atopic asthma, to increase during an exacerbation, to decrease with anti-inflammatory therapy, and to rise as the dose of inhaled steroids is reduced.
ACCESSION #
12915223

 

Related Articles

  • Analysis of sputum in COPD. Maestrelli, P.; Richeldi, L.; Moretti, M.; Fabbri, L. M. // Thorax;Jun2001, Vol. 56 Issue 6, p420 

    It is therefore important to characterize and quantify inflammatory changes in the assessment of subjects with chronic obstructive pulmonary disease. A number of studies have suggested a pathogenetic role for airway inflammation in the induction of both chronic sputum production and chronic...

  • The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD. Russell, Kirsty E.; Chung, Kian Fan; Clarke, Colin J.; Durham, Andrew L.; Mallia, Patrick; Footitt, Joseph; Johnston, Sebastian L.; Barnes, Peter J.; Hall, Simon R.; Simpson, Karen D.; Starkey, Malcolm R.; Hansbro, Philip M.; Adcock, Ian M.; Wiegman, Coen H. // PLoS ONE;1/11/2016, Vol. 11 Issue 1, p1 

    Introduction: Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine associated with acute and chronic inflammatory disorders and corticosteroid insensitivity. Its expression in the airways of patients with chronic obstructive pulmonary disease (COPD), a relatively steroid...

  • Repeatability of and Relationship between Potential COPD Biomarkers in Bronchoalveolar Lavage, Bronchial Biopsies, Serum, and Induced Sputum. Röpcke, Stefan; Holz, Olaf; Lauer, Gereon; Müller, Meike; Rittinghausen, Susanne; Ernst, Peter; Lahu, Gezim; Elmlinger, Martin; Krug, Norbert; Hohlfeld, Jens M. // PLoS ONE;Oct2012, Vol. 7 Issue 10, Special section p1 

    Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory disease, primarily affecting the airways. Stable biomarkers characterizing the inflammatory phenotype of the disease, relevant for disease activity and suited to predict disease progression are needed to monitor the efficacy...

  • Silymarin Attenuates Airway Inflammation Induced by Cigarette Smoke in Mice. Li, Diandian; Xu, Dan; Wang, Tao; Shen, Yongchun; Guo, Shujin; Zhang, Xue; Guo, Lingli; Li, Xiaoou; Liu, Lian; Wen, Fuqiang // Inflammation;Apr2015, Vol. 38 Issue 2, p871 

    Cigarette smoke (CS), which increases inflammation and oxidative stress, is a major risk factor for the development of COPD. In this study, we investigated the effects of silymarin, a polyphenolic flavonoid isolated from the seeds and fruits of milk thistle, on CS-induced airway inflammation and...

  • Cytopathological Aspects in the Bronchoalveolar Lavage Fluid in Chronic Obstructive Pulmonary Disease. PETRESCU, F.; PETRESCU, OCTAVIA ILEANA; SILOSI, ISABELA; TAISESCU, C.; PETRESCU, ANA-MARIA; FORTOFOIU, M. C.; ENESCU, AURELIA; ENESCU, ANCA STEFANIA; CIOBANU, DANIELA; BICIUSCA, V. // Current Health Sciences Journal;2015, Vol. 41 Issue 1, p35 

    Chronic Obstructive Pulmonary Disease (COPD) is a clinical syndrome characterised by a slow progressive decline in expiratory airflow [1], a process that has gradually developed over the years. Studies of patients with COPD show an inflammatory process in the small airways [2]. The aim of this...

  • Untangling the protease web in COPD: metalloproteinases in the silent zone. Johnson, Simon R. // Thorax;Feb2016, Vol. 71 Issue 2, p105 

    The article discusses research on the association of specific aspects of the emphysema phenotype, such as small airway disease and emphysema, with bronchoalveolar lavage matrix metalloproteinase (MMP) and cytokine levels in chronic obstructive pulmonary disease (COPD) patients. It references a...

  • Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection. Papakonstantinou, Eleni; Karakiulakis, George; Batzios, Spyros; Savic, Spasenija; Roth, Michael; Tamm, Michael; Stolz, Daiana // Respiratory Research;Jul2015, Vol. 16 Issue 1, p1 

    Background: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are associated with accelerated aggravation of clinical symptoms and deterioration of pulmonary function. The mechanisms by which exacerbations may contribute to airway remodeling and declined lung function are...

  • Models of chronic obstructive pulmonary disease. Groneberg, David A.; Chung, K. Fan // Respiratory Research;2004, Vol. 5, p18 

    Chronic obstructive pulmonary disease (COPD) is a major global health problem and is predicted to become the third most common cause of death by 2020. Apart from the important preventive steps of smoking cessation, there are no other specific treatments for COPD that are as effective in...

  • Certain Bacterial Colonizations in Newborns Carry Risk of Childhood Asthma. Marshall, Adriene // Pulmonary Reviews;Nov2007, Vol. 12 Issue 11, p41 

    The article discusses research being done on childhood asthma after bacterial colonization of the airway in neonates. It references a study by Hans Bisgaard and colleagues published in the October 11, 2007 issue of the "New England Journal of Medicine." Key findings revealed that throat cultures...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics