EDITORIAL Obstructive nephropathy and the developing kidney: Too little or too much angiotensin?

Chevalier, Robert L.
April 2004
Kidney International;Apr2004, Vol. 65 Issue 4, p1517
Academic Journal
The response of the developing kidney to obstructed urine flow depends on the stage of renal development and the severity of obstruction. Obstruction early in nephrogenesis may lead to renal dysplasia, while obstruction later in nephrogenesis delays nephron maturation. It is clear that major independent determinants of progression of congenital renal disorders include hypertension, proteinuria and the endogenous activity of the renin-angiotensin system. However, caution must be taken in blocking the endogenous renin angiotensin system of the developing kidney.


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