TITLE

Statistical interaction in human genetics: how should we model it if we are looking for biological interaction?

AUTHOR(S)
Xuefeng Wang; Elston, Robert C.; Xiaofeng Zhu; Wang, Xuefeng; Zhu, Xiaofeng
PUB. DATE
January 2011
SOURCE
Nature Reviews Genetics;Jan2011, Vol. 12 Issue 1, p74
SOURCE TYPE
Academic Journal
DOC. TYPE
commentary
ABSTRACT
The article focuses on gene-gene interaction detection in diseases without statistical interaction. It references the article "Detecting gene-gene interactions that underlie human diseases," by H. J. Cordell in the 2009 issue. It tackles the need to jointly interpret statistical interaction and effect terms. It tells that statistical interaction may not be engaged with statistical models since it is population-level and since non-additivity's presence and magnitude are scale and model reliant.
ACCESSION #
56096729

 

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