Rare multiple primary malignancies among surgical patients--a single surgical unit experience

Carlomagno, Nicola; Santangelo, Michele L.; Mastromarino, Rossella; Calogero, Armando; Dodaro, Concetta; Renda, Andrea
June 2014
Ecancermedicalscience;2014, Vol. 8 Issue 413-446, p1
Academic Journal
Case Study
Background: A remarkable number of patients presents with multiple primary malignancies (MPM) over their lifetimes. In most cases inherited syndromes, iatrogenic, or viral factors are implicated, while in some cases it is not possible to ascertain a clear aetiopathogenesis. Methods: Starting from a series of 315 patients with MPM, we focused our attention on those with extremely infrequent combinations of tumours. We retrospectively analysed patients' characteristics, type of first and second tumour and the interval between the two tumours. We made a comparison between our own data and data from surveillance, epidemiology, and end results cancer registries, the largest global series on this topic. Results: Six patients presented with unusual associations, namely, central nervous system (CNS)/colon, testis/stomach, colon/CNS, CNS/kidney, uterus/soft tissue, and bone/breast. The median age was 50.5 years at the diagnosis of second neoplasm and the male:female ratio was 1:1. All six patients underwent surgery for both tumours. The median interval between the first and the second tumour was 11.3 years (range 1-36 years). Five patients were given chemotherapy as adjuvant systemic treatment, and two of them with CNS tumours also received radiotherapy. Discussion: We analysed the behaviour of these rare tumours as first and second neoplasms. More frequent combinations and possible aetiological factors were evaluated. Conclusions: Follow-up for patients recovering from a first tumour must be strict, as there is the risk of developing MPM, even after a long time period. Advancement in biomolecular knowledge and cooperation among different specialists are strongly needed to reduce mortality related to MPM and to foresee their occurrence.


Related Articles

  • Mastectomy vs. Breast-Conserving Therapy for DCIS. Walling, Anne D. // American Family Physician;1/1/2007, Vol. 75 Issue 1, p106 

    The article discusses research being done on breast cancer-specific mortality after invasive local recurrence in patients with ductal carcinoma-in-situ (DCIS) of the breast. It references a study by L. A. Lee et al published in the October 2006 issue of the "American Journal of Surgery."...

  • PROVIDING INDIVIDUALIZED INFORMATION UTILIZING A COMPUTERIZED DECISION SUPPORT INTERVENTION. Davison, B. Joyce; Degner, Lesley; Gleave, Martin; Goldenberg, Larry // Oncology Nursing Forum;Jan2007, Vol. 34 Issue 1, p205 

    Prostate cancer remains the most commonly diagnosed non-skin malignancy and second most common cause of male cancer-related deaths in North America. There is evidence men newly diagnosed with prostate cancer want to be informed and to participate in treatment decision making. However, there is...

  • Lack of Effect of Lowering LDL Cholesterol on Cancer: Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy.  // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000...

  • No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study. Li, Wei-Hua; Zhang, Zi-Guan; Huang, Zheng-Rong; Zhang, Wei; Li, Zhi-Bin; Qi, Zhong-Quan // Cancer Management & Research;Sep2018, Vol. 10, p3649 

    No abstract available.

  • Combining statistical techniques to predict postsurgical risk of 1-year mortality for patients with colon cancer. Arostegui, Inmaculada; Gonzalez, Nerea; Fernández-de-Larrea, Nerea; Lázaro-Aramburu, Santiago; Baré, Marisa; Redondo, Maximino; Sarasqueta, Cristina; Garcia-Gutierrez, Susana; Quintana, Jose M // Clinical Epidemiology;Mar2018, Vol. 10, p235 

    Introduction: Colorectal cancer is one of the most frequently diagnosed malignancies and a common cause of cancer-related mortality. The aim of this study was to develop and validate a clinical predictive model for 1-year mortality among patients with colon cancer who survive for at least 30...

  • Can Erythropoietin Therapy Improve Survival? Glaspy, John; Dunst, Juergen // Oncology;2004 Supplement 1, Vol. 67, p5 

    The presence of anaemia in patients with cancer is correlated with poor clinical outcome, a reduced tumour response to anticancer therapy and an increased risk of mortality. This observation has led to speculation as to whether treatment of anaemia can enhance survival rates. The majority of...

  • Hospital factors and patient characteristics in the treatment of colorectal cancer: a population based study. Sacerdote, Carlotta; Baldi, Ileana; Bertetto, Oscar; DiCuonzo, Daniela; Farina, Enzo; Pagano, Eva; Rosato, Rosalba; Senore, Carlo; Merletti, Franco; Ciccone, Giovannino // BMC Public Health;2012, Vol. 12 Issue 1, p775 

    Background: The present study focuses on the analysis of social, clinical and hospital characteristics that can lead to disparities in the management and outcome of care. To that end, indicators of the quality of initial treatment delivered to newly-diagnosed colorectal cancer patients in a...

  • Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer. Kang, Guhyun; Hwang, Woo Cheol; Do, In-Gu; Wang, Kai; Kang, So Young; Lee, Jeeyun; Park, Se Hoon; Park, Joon Oh; Kang, Won Ki; Jang, Jiryeon; Choi, Min-Gew; Lee, Jun Ho; Sohn, Tae Sung; Bae, Jae Moon; Kim, Sung; Kim, Min Ji; Kim, Seonwoo; Park, Cheol Keun; Kim, Kyoung-Mee // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether...

  • Targeting metastatic colorectal cancer - present and emerging treatment options. Ciombor, Kristen K.; Berlin, Jordan // Pharmacogenomics & Personalized Medicine;2014, Vol. 7, p137 

    Metastatic colorectal cancer is a significant cause of morbidity and mortality in the US and around the world. While several novel cytotoxic and biologic therapies have been developed and proven efficacious in the past two decades, their optimal use in terms of patient selection, drug...

  • Socioeconomic Disparity in Survival after Breast Cancer in Ireland: Observational Study. Walsh, Paul M.; Byrne, Julianne; Kelly, Maria; McDevitt, Joe; Comber, Harry // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1 

    We evaluated the relationship between breast cancer survival and deprivation using data from the Irish National Cancer Registry. Cause-specific survival was compared between five area-based socioeconomic deprivation strata using Cox regression. Patient and tumour characteristics and treatment...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics