TITLE

Elevated cerebrospinal fluid IgG index in acute cerebellitis presenting with sudden onset headache

AUTHOR(S)
Kyung Yeon Lee; Kun-Soo Lee
PUB. DATE
June 2014
SOURCE
Neurology Asia;Jun2014, Vol. 19 Issue 2, p211
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
Acute cerebellitis is a rare inflammatory syndrome and is one of the important causes of acute cerebellar dysfunction in children. The cerebrospinal fluid (CSF) IgG index is most often tested clinically in the diagnosis of multiple sclerosis. However, it is not specific to multiple sclerosis, and can be elevated in a variety of neurologic diseases. A 7-year-old boy with acute cerebellitis presenting with sudden onset headache and subtle cerebellar dysfunction demonstrated an elevated CSF IgG index (1.1) and an absence of oligoclonal bands. On the seventeenth day, the follow-up CSF IgG index was 0.71. Two-month and one-year follow-up magnetic resonance imaging revealed cerebellar atrophy, although the patient showed no neurologic deficit. To the best of our knowledge, this case report is the first to describe acute cerebellitis accompanied by an elevated CSF IgG index and an absence of CSF oligoclonal IgG bands. These findings suggest that a breach in the blood-brain-barrier might occur in acute cerebellitis.
ACCESSION #
96987177

 

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