TITLE

Silicate Urolithiasis during Long-Term Treatment with Zonisamide

AUTHOR(S)
Satoru Taguchi; Yorito Nose; Toshikazu Sato; Teruaki Kobayashi; Kanami Takaya; Akira Ishikawa; Yukio Homma
PUB. DATE
January 2013
SOURCE
Case Reports in Medicine;2013, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
Silicate urinary calculi are rare in humans, with an incidence of 0.2% of all urinary calculi. Most cases were related to excess ingestion of silicate, typically by taking magnesium trisilicate as an antacid for peptic ulcers over a long period of time; however, there also existed unrelated cases, whose mechanism of development remains unclear. On the other hand, zonisamide, a newer antiepileptic drug, is one of the important causing agents of iatrogenic urinary stones in patients with epilepsy. The supposed mechanism is that zonisamide induces urine alkalinization and then promotes crystallization of urine components such as calcium phosphate by inhibition of carbonate dehydratase in renal tubular epithelial cells. Here, we report a case of silicate urolithiasis during long-term treatment with zonisamide without magnesium trisilicate intake and discuss the etiology of the disease by examining the silicate concentration in his urine.
ACCESSION #
95100049

 

Related Articles

  • Bacterial Mucosal Infiltration in Helicobacter pylori-associated Gastritis: Histological and Clinical Consequences. Neri, Matteo; Susi, Danilo; Bovani, Iva; Laterza, Francesco; Mezzetti, Andrea; Cuccurullo, Franco // American Journal of Gastroenterology;Oct1994, Vol. 89 Issue 10, p1801 

    Objectives: We wished to demonstrate that gastric epithelial cells infiltration by HP is associated with the active inflammatory response and the severity of gastritis in the gastric antrum of patients harboring the bacterium. Methods: We studied 129 patients with HP-associated gastritis and 60...

  • Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam. Nguyen, L. T.; Uchida, T.; Tsukamoto, Y.; Trinh, T. D.; Ta, L.; Mai, H. B.; Le, H. S.; Ho, D. Q. D.; Hoang, H. H.; Matsuhisa, T.; Okimoto, T.; Kodama, M.; Murakami, K.; Fujioka, T.; Yamaoka, Y.; Moriyama, M. // European Journal of Clinical Microbiology & Infectious Diseases;Jun2010, Vol. 29 Issue 6, p651 

    The purpose of this paper is to investigate the relationship between clinical outcome and the intactness of cagPAI in Helicobacter pylori strains from Vietnam. The presence or absence of 30 cagPAI genes was investigated by polymerase chain reaction (PCR) and dot-blotting. H. pylori-induced...

  • Campylobacter pyloridis: what role in gastritis and peptic ulcer? Axon, A.T.R. // British Medical Journal (Clinical Research Edition);9/27/1986, Vol. 293 Issue 6550, p772 

    Examines the role of campylobacter pyloridis in gastritis and peptic ulcer. Historical evidence of gastritis; Location of the organisms in the surface of gastric epithelial cells; Clinical relevance of the association between gastritis and C pyloridis.

  • Relation Between vacA Subtypes, Cytotoxin Activity, and Disease in Helicobacter pylori-Infected Patients From The Netherlands. Zhi-Jun Pan; Van der Hulst, RenĂ© W. M.; Tytgat, Guido N. J.; Dankert, Jacob; Van der Ende, Arie // American Journal of Gastroenterology;Jun1999, Vol. 94 Issue 6, p1517 

    OBJECTIVE: The vacuolating cytotoxin of Helicobacter pylori (H. pylori) is encoded by vacA, of which allelic variation has been described. In the U.S., H. pylori strains with the signal sequence allele s1a are associated with enhanced gastric inflammation and...

  • Fighting the fire: Managing and preventing peptic ulcer disease in the multi-risk patient. Cerda, James J.; Fowler, Fred C. // Modern Medicine;Jan94, Vol. 62 Issue 1, p40 

    Discusses factors to consider in diagnosing, treating and managing peptic ulcer. Drugs increasing risks of the ulcer occurrence; Helicobacter pylori in causing peptic ulcer; Treatment options; Recurrence avoidance. INSETS: The American lesion.;The theory of diet as a pathogen is hard to...

  • Management strategies in suspected peptic ulcer disease.  // American Family Physician;11/1/1995, Vol. 52 Issue 6, p1890 

    Reports on an article published by Fendrick and associates in the August 15, 1995 issue of the `Annals of Internal Medicine' on management strategies in suspected peptic ulcer disease.

  • Epidemiological Study of Perforation of Gastric Peptic Ulcer in Patients Admitted to Poursina Hospital. Farzan, Ramyar; Behboodi, Firooz; Sade, Behjat; Nejad, Ehsan Kazem // Zahedan Journal of Research in Medical Sciences;Apr2015, Vol. 17 Issue 4, p1 

    A letter to the editor is presented in response to the article "Perforated peptic ulcer in Khartoum" by E. Elnagib and colleagues.

  • LOCALIZATION OF CagA EFECTOR PROTEIN OF HELICOBACTER PYLORI IN INFECTED EPITHELIAL CELLS. Lancrajan, Ioana; Kogalniceanu, Svetlana; Ardelean, Doru; Ardelean, Gavril // Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life ;2011, Vol. 21 Issue 4, p709 

    Epidemiological studies have shown the role of CagA-positive Helicobacter pylori (Hp) in development of atrophic gastritis, peptic ulcer disease and gastric carcinoma. CagA effector protein of bacterial pathogen Helicobacter pylori is translocated in host cell via TFSS and subsequently tyrosine...

  • Helicobacter pylori in a Korean isolate expressed proteins differentially in human gastric epithelial cells. Soon Ok Cho; Joo Weon Lim; Jong-Ho Jun; Kyung Hwan Kim; Hyeyoung Kim; Cho, Soon Ok; Lim, Joo Weon; Jun, Jong-Ho; Kim, Kyung Hwan; Kim, Hyeyoung // Digestive Diseases & Sciences;Jun2010, Vol. 55 Issue 6, p1550 

    Purpose: The proteins expressed in gastric epithelial cells infected with Helicobacter pylori (H. pylori) may determine the clinical outcome such as chronic gastritis, peptic ulcer, and gastric carcinoma. The present study aims to determine the differentially expressed proteins in...

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics