TITLE

Serum IL-21 levels associated with chronic hepatitis B and hepatitis B-related liver failure

AUTHOR(S)
HONG-MEI CHEN; HONG-LI LIU; YU-CONG YANG; XIAO-LI CHENG; YUE-FEI WANG; FAN-FAN XING; YING-REN ZHAO
PUB. DATE
April 2014
SOURCE
Experimental & Therapeutic Medicine;2014, Vol. 7 Issue 4, p1013
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
The aim of the present study was to investigate the role of interleukin (IL)-21 in chronic hepatitis B virus (HBV) infection. IL-21 stimulates T and B cell responses and plays a role in the control of chronic viral infections. Serum IL-21 levels were measured by enzyme immunoassay in 109 patients with chronic HBV infection at various clinical stages, as well as in 19 healthy controls (HCs). The proportion of T cells producing IL-21 in the peripheral blood was assessed by intracellular cytokine staining and low cytometry. Mean serum IL-21 levels in patients with chronic hepatitis B (CHB) and the HCs were 303.54±152.77 pg/ml and 68.24±9.06 pg/ml, respectively (P=0.003). In addition, the mean serum IL-21 level in patients with hepatitis B-related acute-on-chronic liver failure (HB-ACLF) was 455.38±412.38 pg/ml, which exhibited a statistically significant difference when compared with the HCs (P=0.000). Serum IL-21 levels were highest in the patients with HB-ACLF (455.38±412.38 pg/ml) and exhibited a significant difference when compared with the CHB patients (P=0.04). The mean serum IL-21 levels in patients with cirrhosis also increased, but there was no statistically significant difference when compared with the HCs (P=0.82). The frequency of IL-21+CD4+ cells also increased compared with the HCs and correlated with the number and percentage of lymphocytes in the peripheral blood. Serum IL-21 levels increased in CHB and HB-ACLF patients. Relatively low serum IL-21 levels in CHB may have a causal role in the persistence of HBV infection. Higher serum levels in HB-ACLF may activate T and B cells to eliminate the virus or injure the liver via the release of inflammatory cytokines.
ACCESSION #
94754508

 

Related Articles

  • Upregulation of Tim-3 on CD4+ T cells is associated with Th1/Th2 imbalance in patients with allergic asthma. Fei Tang; Fukun Wang; Liyun An; Xianling Wang // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 3, p3809 

    T cell Ig and mucin domain-containing molecule-3 (Tim-3) is a negative regulator preferentially expressed on Th1 cells. Allergic asthma is a clinical syndrome well characterized by Th1/Th2 imbalance. To investigate the role of Tim-3 in the pathogenesis of asthma and its relationship with Th1/Th2...

  • Beneficial Effects of Bushen Formula Combined with Enticavir on Chronic Hepatitis B Patients with Suboptimal Response to Enticavir by Regulating B-Cell Differentiation. Li, Man; Zhou, Zhen-Hua; Bao, Ting; Zhang, Xin; Zhu, Xiao-Jun; Jin, Shu-Gen; Gao, Ya-Ting; Sun, Xue-Hua; Gao, Yue-Qiu // Cellular Physiology & Biochemistry (Karger AG);Aug2018, Vol. 48 Issue 2, p633 

    Background/Aims: To investigate the clinical effects of the combination therapy with Bushen Formula (BSF) plus enticavir (ETV) on chronic hepatitis B (CHB) patients with suboptimal response to ETV and explore the regulatory mechanisms of BSF on B cells-mediated humoral immunity....

  • Non-association of IL-12 +1188 and IFN-γ +874 Polymorphisms with Cytokines Serum Level in Occult HBV Infected Patients. Arababadi, Mohammad K.; Pourfathollah, Ali A.; Jafarzadeh, Abdollah; Hassanshahi, Gholamhossein; Daneshmandi, Saeed; Shamsizadeh, Ali; Kennedy, Derek // Saudi Journal of Gastroenterology;Jan2011, Vol. 17 Issue 1, p30 

    Background/Aim: Occult hepatitis B infection (OBI) is identified as a form of hepatitis in which despite the absence of detectable HBsAg, HBV-DNA is observed in peripheral blood of patients. The main aim of this study has been to investigate the association between polymorphisms in +874 of...

  • Effect of interleukin 21 and its receptor on CD8+ T cells in the pathogenesis of diffuse large B-cell lymphoma. ZHANSHAN CHA; HAIHUI GU; HUIJUN GUO; XIAOHUA TU; YAN ZANG; CHUNYAN ZHAO; MEIXIAN HUA; RECHLIC, JAMES R.; OLASNOVA, LINDSAY M.; HAIHAN SONG; BAOHUA QIAN // Oncology Letters;2014, Vol. 8 Issue 1, p421 

    Interleukin 21 (IL-21) and its receptor, IL-21R, play a key role in innate and adaptive immunity. In the present study, the effect of IL-21 and IL-21R on the pathogenesis of diffuse large B-cell lymphoma (DLBCL) was investigated. The serum levels of IL-21 were detected by enzyme-linked...

  • Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival. Moura, Rita A.; Cascão, Rita; Perpétuo, Inês; Canhão, Helena; Vieira-Sousa, Elsa; Mourão, Ana F.; Rodrigues, Ana M.; Polido-Pereira, Joaquim; Queiroz, Mário V.; Rosário, Henrique S.; Souto-Carneiro, Maria M.; Graca, Luis; Fonseca, João E. // Rheumatology;Feb2011, Vol. 50 Issue 2, p278 

    Objectives. B cells play an important role in the perpetuation of RA, particularly as autoantibody-producing cells. The ICs that further develop deposit in the joints and aggravate the inflammatory process. However, B-cell contribution in the very early stage of the disease remains unknown. The...

  • B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection. Shiu, Kin Y; McLaughlin, Laura; Rebollo-Mesa, Irene; Zhao, Jingyue; Semik, Vikki; Cook, H Terence; Roufosse, Candice; Brookes, Paul; Bowers, Robert W; Galliford, Jack; Taube, David; Lechler, Robert I; Hernandez-Fuentes, Maria P; Dorling, Anthony // Kidney International;Sep2015, Vol. 88 Issue 3, p560 

    We explored how B-lymphocytes influence in vitro T-cell alloresponses in patients with antibody-mediated rejection (AMR), testing whether B-cells would be preferentially involved in this group of patients. Peripheral blood mononuclear cells were collected from 65 patients having biopsy: 14...

  • Knockdown of Akt Sensitizes Osteosarcoma Cells to Apoptosis Induced by Cisplatin Treatment. Guoyou Zhang; Ming Li; Xiaodong Zhu; Yushu Bai; Changwei Yang // International Journal of Molecular Sciences;May2011, Vol. 12 Issue 5, p2994 

    Akt plays an important role in the inhibition of apoptosis induced by chemotherapy and other stimuli. We therefore investigated if knockdown of Akt2 promoted drug-induced apoptosis in cultured osteosarcoma cells in vitro. SAOS-2 cells were transfected with Akt2 siRNA. The sensitivity of the...

  • Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes. Chung, Chi-Li; Leung, Kam-Wing; Lu, Wan-Jung; Yen, Ting-Lin; He, Chia-Fu; Sheu, Joen-Rong; Lin, Kuan-Hung; Lien, Li-Ming // Evidence-based Complementary & Alternative Medicine (eCAM);8/26/2015, Vol. 2015, p1 

    Autoimmune diseases are a group of chronic inflammatory diseases that arise from inappropriate inflammatory responses. Hinokitiol, isolated from the wood of Chamaecyparis taiwanensis, engages in multiple biological activities. Although hinokitiol has been reported to inhibit inflammation, its...

  • Elevated Production of B Cell Chemokine CXCL13 is Correlated with Systemic Lupus Erythematosus Disease Activity. Wong, C. K.; Wong, Purple T. Y.; Tam, L. S.; Li, Edmund K.; Chen, D. P.; Lam, Christopher W. K. // Journal of Clinical Immunology;Jan2010, Vol. 30 Issue 1, p45 

    B lymphocyte chemoattractant (BLC/CXCL13), a CXC chemokine, is involved in B1 and B2 cell trafficking for the activation of autoreactive T helper (Th) cells and autoantibody production in target organs during the development of lupus. CXCL13 can induce the trafficking of CXCR5+ T lymphocyte...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics