TITLE

Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib

AUTHOR(S)
Kermiche-Rahali, Sabrina; Di Fiore, Aude; Drieux, Fanny; Di Fiore, Frédéric; François, Arnaud; Scotté, Michel
PUB. DATE
September 2013
SOURCE
World Journal of Surgical Oncology;2013, Vol. 11 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Case Study
ABSTRACT
Sorafenib is a molecular-targeted therapy used in palliative treatment of advanced hepatocellular carcinoma (HCC) in Child-Pugh A patients. We describe the case of a patient who presented with a large HCC in the left liver associated with portal vein thrombosis (PVT). After 9 months of sorafenib treatment, reassessment showed that the tumors had decreased in size with recanalization of the portal vein. A lateral left hepatectomy was performed and pathology showed complete necrosis of the tumor. Sorafenib can downstage HCC in patients with cirrhosis allowing further surgical resection.
ACCESSION #
90275096

 

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