Three further cases of t(8;14)(q11.2;q32) in acute lymphoblastic leukemia

Byatt, S-A; Cheung, K-L; Lillington, D M; Mazzullo, H; Martineau, M; Bennett, C; Roberts, K; Harewood, L; Sumption, N; Humphreys, M; Burrett, J; Harrison, C J
August 2001
Leukemia (08876924);Aug2001, Vol. 15 Issue 8, p1304
Academic Journal
case study
Focuses on three cases of acute lymphoblastic leukemia with rare chromosomal translocation in Great Britain. Identification of patients through Acute Lymphoblastic Leukemia database; Cytogenetic analysis on diagnostic bone marrow samples in laboratories; Chromosomal changes observed in the patients.


Related Articles

  • Identification of a novel molecular partner of the E2A gene in childhood leukemia. Brambillasca, F; Mosna, G; Colombo, M; Rivolta, A; Caslini, C; Minuzzo, M; Giudici, G; Mizzi, L; Biondi, A; Privitera, E // Leukemia (08876924);Mar99, Vol. 13 Issue 3, p369 

    The 'promiscuous' E2A gene, at 19p13.3, is fused with two different molecular partners, PBX1 and HLF, following two chromosome translocations recurrent in childhood pre-B ALL. We have identified a novel gene, FB1, by virtue of its fusion with E2A and by a combination of molecular techniques. FB1...

  • The heterodimerization domains of MLL-FYRN and FYRC--are potential target structures in t(4;11) leukemia. Pless, B.; Oehm, C.; Knauer, S.; Stauber, R. H.; Dingermann, T.; Marschalek, R. // Leukemia (08876924);Apr2011, Vol. 25 Issue 4, p663 

    The chromosomal translocation t(4;11)(q21;q23) is a frequent genetic aberration of the mixed lineage leukemia (MLL) gene, predominantly associated with high-risk acute lymphoblastic leukemia (ALL) in pediatric patients. Previous studies demonstrated that mice transplanted with hematopoietic...

  • FISHing for Chromosomal Abnormalities in Acute Lymphoblastic Leukaemia. Harrison, Christine // Journal of Medical Genetics;Sep2003 Supplement, Vol. 40, pS29 

    Chromosomal abnormalities in acute lymphoblastic leukaemia (ALL) are linked to outcome. In particular, the Ph chromosome/BCR/ABL fusion, MLL gene rearrangements/11q23 abnormalities and nearhaploidy (23-28 chromosomes) are high-risk. The cryptic translocation, t(12;21)(p13;q22)/ETV6/AML1 fusion,...

  • Resistance of t(4;11) (MLL-AF4 fusion gene) leukemias to stress-induced cell death: possible mechanism for extensive extramedullary accumulation of cells and poor prognosis. Kersey, J H; Wang, D; Oberto, M // Leukemia (08876924);Oct98, Vol. 12 Issue 10, p1561 

    Acute leukemias of the t(4;11) (MLL-AF4 fusion gene) type frequently have high white blood counts and extramedullary disease in multiple organs. In the present study we evaluated the hypotheses that this extensive disease is the result of extramedullary survival of leukemia cells due to...

  • Chromosomal aberrations and schizophrenia. Autosomes. Bassett, Anne S.; Bassett, A S // British Journal of Psychiatry;Sep92, Vol. 161, p323 

    Chromosomal aberrations associated with schizophrenic disorders may suggest regions in which to focus a search for genes predisposing to schizophrenia by a linkage strategy. As for other genetic illnesses, chromosomal abnormalities may also provide useful tools for subsequent physical mapping,...

  • G(2) chromosomal radiosensitivity in Danish survivors of childhood and adolescent cancer and their offspring. Curwen, G B; Winther, J F; Tawn, E J; Smart, V; Whitehouse, C A; Rees, G S; Olsen, J H; Guldberg, P; Rechnitzer, C; Schrøder, H; Bryant, P E; Sheng, X; Lee, H S; Chakraborty, R; Boice, J D // British Journal of Cancer;10/31/2005, Vol. 93 Issue 9, p1038 

    In order to investigate the relationship between chromosomal radiosensitivity and early-onset cancer, the G(2) chromosomal radiosensitivity assay was undertaken on a group of 23 Danish survivors of childhood and adolescent cancer, a control group comprising their partners and a group of 38 of...

  • Syndromes of acute nonlymphocytic leukemia. Koeffler, H. Phillip; Koeffler, H P // Annals of Internal Medicine;Nov87, Vol. 107 Issue 5, p748 

    The marriage of cytogenetics and molecular biology has resulted in major advances in our understanding of acute nonlymphocytic leukemia. These technologies reveal a number of clearly recognizable syndromes of acute nonlymphocytic leukemia. This review describes the salient features of several of...

  • Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis) Craddock, Nick; Owen, Mike; Burge, Susan; Kurian, Bobby; Thomas, Phil; McGuffin, Peter; Craddock, N; Owen, M; Burge, S; Kurian, B; Thomas, P; McGuffin, P // British Journal of Psychiatry;Mar94, Vol. 164, p355 

    Darier's disease is a rare autosomal dominantly inherited keratosis. This is an account of one family in which there is co-occurrence of major affective disorder and Darier's disease in five members and absence of both disorders in five members. The pedigree is consistent with genetic linkage...

  • An examination of linkage of schizophrenia and schizoaffective disorder to the pseudoautosomal region (Xp22.3) Crow, Timothy J.; Delisi, Lynn E.; Lofthouse, Raymond; Poulter, Mark; Lehner, Thomas; Bass, Nicholas; Shah, Tarulata; Walsh, Catherine; Boccio-Smith, Angela; Shields, Gail; Ott, Jurg; Crow, T J; Delisi, L E; Lofthouse, R; Poulter, M; Lehner, T; Bass, N; Shah, T; Walsh, C; Boccio-Smith, A // British Journal of Psychiatry;Feb94, Vol. 164, p159 

    We investigated linkage between schizophrenia and the loci DXYS14, DXYS17, and MIC2 within the pseudoautosomal region in 85 families with two or more siblings suffering from schizophrenia or schizoaffective disorder. A maximum lod score of 2.44 was reached at MIC2, with a dominant model of...

  • A multiplex RT-PCR assay for the detection of chimeric transcripts encoded by the risk-stratifying translocations of pediatric acute lymphoblastic leukemia. Scurto, P; Rocha, M Hsu; Kane, J R; Williams, W K; Haney, D M; Conn, W P; Shurtleff, S A; Downing, J R; Hsu Rocha, M // Leukemia (08876924);Dec98, Vol. 12 Issue 12, p1994 

    Modern therapy for pediatric acute lymphoblastic leukemia (ALL) is based on the principle of risk stratification. One of the most important laboratory features used to accurately risk stratify patients is the presence of specific chromosomal translocation within the leukemic blasts. In this...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics