Variation in persistent hyperplastic primary vitreous

ONKAR, Deepali Prashant; ONKAR, Prashant Madhukar
January 2013
International Journal of Anatomical Variations;2013, Vol. 6, p68
Academic Journal
Case Study
Persistent hyperplastic primary vitreous is a result of failure of regression of embryonic hyaloid artery. It leads to abnormal lenticular development and secondary changes in retina and orbit. It presents as leucocoria and the eye is usually microphthalmic. High frequency ultrasound usually demonstrates an echogenic mass posterior to the lens with a hyperechoic band extending from the optic disc to the posterior surface of the retrolental mass, corresponding to the hyaloid canal. Visualization of hyaloid artery in this canal with color Doppler imaging is almost pathognomonic. A 3-month-old male infant presented with a unilateral leucocoria. High frequency ultrasound revealed echogenic band extending from optic disc to posterior aspect of lens. No retrolental mass was noted. On color Doppler, this band showed vascular pulsatile color flow in the persistent hyaloid artery. Color Doppler was diagnostic in this variant of persistent hyperplastic primary vitreous where retrolental mass was absent.


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