A Chronic Myelogenous Leukemia (CML) Case with a Cryptic Insertion of the ABL1 Gene of Chromosome 9 into 22 Resulting in a Fusion Signal on the Derivative 22: 46,XY.ish ins(22;9)(q11 .2;q34q34)BCR+,ABL1 +
- Molecular cytogenetic characterization of Philadelphia-negative rearrangements in chronic myeloid leukemia patients. Bennour, Ayda; Bellâaj, Hatem; Ben Youssef, Yosra; Elloumi, Moez; Khelif, Abderrahim; Saad, Ali; Sennana, Halima // Journal of Cancer Research & Clinical Oncology;Sep2011, Vol. 137 Issue 9, p1329
Background: The BCR/ABL gene rearrangement is generated by a reciprocal translocation t(9;22)(q34;q11) in chronic myeloid leukemia (CML) patients. In most cases, it is cytogenetically visualized by the Philadelphia (Ph) chromosome. About 5-10% of CML patients lack cytogenetic evidence of the Ph...
- A rare t (9; 12; 22) (q34; q23; q11) translocation in a patient with typical chronic myeloid leukemia: A case report. Azma, Raja Z.; Jaapar, Noor A.; Alauddin, Hafiza; Aziz, Suria A.; Ithnin, Azlin; Hussin, Noor H.; Kit, Chia W.; Tumian, Rafeah; Zakaria, Zubaidah; Akmal, Sharifah N.; Shuib, Salwati // Journal of Hematological Malignancies;Dec2012, Vol. 2 Issue 4, p17
Chronic myeloid leukaemia (CML) is typically associated with reciprocal translocation between long arms of chromosome 9 and 22, t (9, 22) (q34; q11.2) and with the formation of a BCR-ABL fusion gene. In a minority of newly diagnosed CML cases, complex cytogenetic variants of the Ph chromosome...
- De novo CSF3R mutation associated with transformation of myeloproliferative neoplasm to atypical CML. Bartels, S.; Lehmann, U.; Büsche, G.; Schlue, J.; Hussein, K.; Debatin, D.; Karcher, A.; Andrulis, M.; Schirmacher, P.; Kreipe, H. // Annals of Hematology;Jul2015, Vol. 94 Issue 7, p1255
The article presents a case-study of a 65-year-old male, who was presented with thrombocytosis, splenomegaly, anemia and signs of hemolysis. Topics discussed include proliferation of all cell lineages displayed by bone marrow histology, myeloproliferative neoplasm showed by splenectomy and...
- Nilotinib. // Reactions Weekly;Feb2015, Vol. 1540 Issue 1, p219
The article presents a case study of a patient who had experienced a moderate transaminase elevation after switching from imatinib to nilotinib treatment for chronic myeloid leukaemia.
- Recurrent Monosomies Confirmed by Interphase FISH in Three Chronic Myeloid Leukemia Cases. Argüden, Yelda Tarkan; Kuru, Dilhan; Çırakoğlu, Ayşe; Yılmaz, Şükriye; Aydın, Şeniz Öngören; Ar, Cem Muhlis; Deviren, Ayhan; Soysal, Teoman; Hacıhanefioğlu, Seniha // Turkish Journal of Hematology;2015, Vol. 32 Issue 1, p82
The article presents a case study of three patients with chronic myeloid leukemia who underwent fluorescence in situ hybridization (FISH) to evaluate significance of these recurrent monosomies. It mentions that patients were treated with imatinib. The study highlights the effectiveness of FISH...
- Imatinib. // Reactions Weekly;2/20/2016, Vol. 1589 Issue 1, p125
An abstract of the article "Outcomes of patients with chronic phase CML who discontinued ponatinib in the frontline setting" by P. Jain and others is presented.
- Imatinib. // Reactions Weekly;2/20/2016, Vol. 1589 Issue 1, p124
An abstract of the article "The efficacy and tolerability of generic of imatinib in a very specific group of chronic myeloid leukemia (CML)" by M. Conchon and others is presented.
- Deletion of ABL/BCR on der(9) associated with severe basophilia. Vaidya, Shantashri; Madkaikar, Manisha; Ghosh, Kanjaksha; Vundinti, Babu Rao // Indian Journal of Human Genetics;May-Aug2011, Vol. 17 Issue 2, p100
Chronic basophilic leukemia is a rare form in chronic myeloid leukemia patients. Only limited number of reports are available. Herein, we describe a patient who presented with fatigue, weight loss, leucocytosis, prominent basophilia, and mild eosinophilia. On biopsy, bone marrow was...
- Correlation between missed abortion and insertional translocation involving chromosomes 1 and 7. Ashaat, Neveen; Husseiny, Ahmed // Iranian Journal of Reproductive Medicine;Winter2012, Vol. 10 Issue 1, p15
Background: Missed abortion (Silent miscarriage) is defined as intrauterine fetal death before twenty weeks gestation. One of the most common causes of early missed abortions (before 10 weeks gestation) is cytogenetic abnormalities. Objective: To asses if there is a correlation between...