Osteopetrosis (Marble Bone Disease): A Rare Disease in Children

Reddy, M. H. Raghunath
September 2011
International Journal of Clinical Pediatric Dentistry;Sep-Dec2011, Vol. 4 Issue 3, p232
Academic Journal
Case Study
Osteopetrosis is a group of diseases that affects the growth and remodeling of bone and characterized by over growth and sclerosis of bone, with thickening of the bony cortices, abnormal dental development and narrowing of the marrow cavities throughout the skeleton. It is an uncommon disease of unknown cause. A 5-year-old boy was suffering from infantile (severe form) osteopetrosis with cardiac enlargement, severe anemia, hepatosplenomagaly and radiographs showed generalized increase in bone density (chalky white), narrowing of skull base is reported here.


Related Articles

  • Famlial nonsyndromic oligodontia. Punithavathy; John, John B.; Priya, Geetha; Elango, Indhumathi; Stalin // Contemporary Clinical Dentistry;Sep2012 Supplement, Vol. 3, pS188 

    Oligodontia is one of the most common developmental abnormalities in humans. The present case report highlights the features of oligodontia in a 12-year-old male patient which was managed successfully with multidisciplinary approach. Familial oligodontia represents as an absence of varying...

  • Infantile Osteopetrosis and Juvenile Xanthogranuloma Presenting Together in a Newborn: A Case Report and Literature Review. Almarzooqi, Saeeda; Reed, Suzanne; Fung, Bonita; Bou, Daniel R.; Prasad, Vinay; Pietryga, Daniel // Pediatric & Developmental Pathology;Jul/Aug2011, Vol. 14 Issue 4, p307 

    Osteopetrosis (OP) is a clinically and genetically heterogeneous disorder characterized by increased bone density. Associations between OP and other clinical entities are rare but include muscular degeneration, Dandy-Walker syndrome, craniosynostosis, and poikiloderma. Infantile OP has also been...

  • PRIMARY DOUBLE TOOTH: A CASE REPORT AND REVIEW OF LITERATURE. P., Thejokrishna; S., Meghana // Annals & Essences of Dentistry;Jan-Mar2012, Vol. 4 Issue 1, p68 

    A number of developmental anomalies can be encountered in clinical situations, which directly or indirectly can affect the treatment plan. These anomalies in the primary dentition can be of immense clinical sighificance since they can have a bearinq on the permanent dentition. Here we report a...

  • Debridement in chronic osteomyelitis with benign osteopetrosis: A case report. YU-PING LIU; XIANG-HUA LIN; MAN-YUN YAN; BAO-QUAN LIN; MING-YING ZHUO // Experimental & Therapeutic Medicine;Nov2016, Vol. 12 Issue 5, p2811 

    Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an...

  • Multiple Trauma in a 5 Years Child with a Longitudinal Follow Up. da Silva Assunção, Luciana Reichert; Bianco, Karina Gerhardt; Santos Silva, Pedro Ivo; Favretto, Carla Oliveira; Cunha, Robson Frederico // Journal of Trauma & Treatment;2012, Vol. 1 Issue 8, p1 

    Dental-alveolar trauma in the primary dentition associated with intra-cranial injuries is not common. This article reports the management of a complex trauma involving cranial trauma and multiple luxations and avulsions of primary teeth in a five-year old boy as a consequence of a horse kick....

  • Malignant infantile osteopetrosis. Kumar, Kalenahalli Jagadish; Bandaru, Kasi; Prashanth, Sathya Narayana; Mamatha, Sangaraju // Indian Journal of Human Genetics;Jan-Mar2013, Vol. 19 Issue 1, p90 

    Osteopetrosis, a rare congenital genetic disease characterized by increased bone density due to impaired bone resorption by osteoclasts. It is classified into three forms: Infantile malignant autosomal recessive (AR) osteopetrosis, intermediate (AR) osteopetrosis and autosomal dominant (AD)...

  • The Use of Characterized Gingival Porcelain to Restore Hard and Soft Tissue Deficiencies. Da Fonseca, Dickson Martins; Ankli, Rolf; C�mara, Carlos Alexandre // Quintessence of Dental Technology (QDT);2002, Vol. 25, p117 

    The article describes the case of a 37-year-old female who wanted to replace her removable partial denture with a fixed partial denture. She also has missing teeth, including the maxillary arch and both central incisors. With this, the patient was given fixed partial denture with two pontics...

  • Prevalence of the Talon Cusp at the Lateral Incisors of Two Individuals of Greek Origin--a Case Study. Zafiri, Vasiliki; Pitsios, Theodoros // International Journal of Caring Sciences;Sep-Dec2010, Vol. 3 Issue 3, p91 

    Background Dental morphological traits are useful for providing information for phylogenic and genetic studies within and among species and populations. Studies of dental traits in the very interesting geographic area of Greece can provide important data on the genetic constitution and the...

  • TRANSMIGRATION OF MANDIBULAR CANINE. Nagaraj, Tejavathi; Senior, Umashree N. // E-Journal of Dentistry;Jul2011, Vol. 1 Issue 3, p72 

    Failure of eruption of the mandibular canine is an unusual event. An unerupted tooth occasionally migrates to a location some distance away from the site in which it developed, but it usually remains within the same side of the arch. The mandibular permanent canine is the only tooth in the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics