A rare case of an aldosterone secreting metastatic adrenocortical carcinoma and papillary thyroid carcinoma in a 31-year-old male

Wanta, Stephen M.; Basina, Marina; Chang, Steven D.; Chang, Daniel T.; Ford, James M.; Greco, Ralph; Kingham, Kerry; Merritt, Robert E.; Kunz, Pamela L.
December 2011
Rare Tumors;2011, Vol. 3 Issue 4, p141
Academic Journal
Case Study
We report a rare synchronous presentation of adrenocortical carcinoma (ACC) and papillary thyroid carcinoma (PTC). A 31-year-old male first presented with a large left adrenal mass that was identified during the workup for refractory hypertension due to hyperaldosteronism. The mass was removed surgically with pathology showing ACC. The patient was then treated with adjuvant radiation therapy and mitotane chemotherapy. Four months post ACC resection, metastatic ACC to the right upper lung and PTC in the left lobe of the thyroid were found in surveillance imaging. He subsequently developed pulmonary, contralateral adrenal and brain metastases from his ACC. Li Fraumeni syndrome and Multiple Endocrine Neoplasia Type I (MEN I) were considered, but testing of both P53 and menin genes showed no mutation. We also performed a review of the literature and found three similar cases, however gene mutation analysis was not performed..


Related Articles

  • A Rare Combination Consisting of Primary Hyperaldosteronism and Glucagonoma. Abe, Hideki; Kubota, Keiichi; Noie, Tamaki; Kimura, Wataru; Makuuchi, Masatoshi // American Journal of Gastroenterology;May1999, Vol. 94 Issue 5, p1397 

    A 59-yr-old man with multiple pancreatic tumors is presented. Previously, he had undergone left adrenalectomy for primary hyperaldosteronism and left nephrectomy for renal cell carcinoma at the ages of 39 and 55 yr. respectively. This time, 3 yr after removal of renal cancer, two solid lesions...

  • Adrenocortical Carcinoma With Concomitant Myelolipoma in a Patient With Hyperaldosteronism. Sun, Xichun; Ayala, Alberto; Castro, Claudia Y. // Archives of Pathology & Laboratory Medicine;Jun2005, Vol. 129 Issue 6, pe144 

    We present a case of aldosterone-secreting adrenocortical carcinoma with concomitant myelolipoma. To the best of our knowledge, this is the first such reported case. The patient was a 43-year-old man with severe hypertension. Clinical workup revealed an increased serum aldosterone level,...

  • Aldosterone-Producing Adrenocortical Carcinoma. Arteaga, Eugenio; Biglieri, Edward G.; Kater, Claudio; Lopez, Jose M.; Schambelan, Morris // Annals of Internal Medicine;Sep84, Vol. 101 Issue 3, p316 

    Presents information on a study that examined three patients with primary aldosteronism due to adrenocortical carcinoma. Research methods; Results and discussion.

  • Secondary Aldosteronism.  // Encyclopedic Reference of Molecular Pharmacology;2004, p843 

    An encyclopedia entry for "secondary aldosteronism," which refers to the condition in which the plasma aldosterone concentration is above the normal range due to various pathophysiological states, is presented.

  • Primary Aldosteronism. Weinberger, Myron H.; Grim, Clarence E.; Hollifield, John W.; Kem, David C.; Ganguly, Arunabha; Kramer, Norman J.; Yune, Heun Y.; Wellman, Henry; Donohue, John P. // Annals of Internal Medicine;Mar79, Vol. 90 Issue 3, p386 

    Presents information on a study which examined the diagnostic techniques used for the detection of primary aldosteronism. Methodology; Results; Discussion.

  • Primary acquired hypoaldosteronism. Kokko, Juha P. // Kidney International;Apr1985, Vol. 27 Issue 4, p690 

    Focuses on the study concerning the primary acquired hypoaldosteronism. Presentation of a case study involving a woman with the disorder; Periods of weakness experienced by the patient; Result of the urinalysis of the patient.

  • Predicting the Likelihood of Additional Nodal Metastases in Breast Carcinoma Patients With Positive Sentinel Node Biopsy. Mustać, Elvira; Matušan-Ilijaš, Koviljka; Marijić, Blažen; Smokvina, Miljenko; Jonjic, Nives // International Journal of Surgical Pathology;Feb2010, Vol. 18 Issue 1, p36 

    Axillary lymph node dissection (ALND) is an important procedure in the staging of breast cancer patients. However, it is associated with a significant morbidity rate. In addition, using early diagnosis a high number of cases with negative lymph nodes can be identified. A lymph node defined as...

  • A patient with concurrent primary aldosteronism and Page kidney. Chin-Chi Kuo; Huan-Lun Hsu; Chao-Yuan Huang; Kao-Lang Liu; Vin-Cent Wu; Ching-Wei Tsai; Wei-Jie Wang // Endocrine (1355008X);Aug2010, Vol. 38 Issue 1, p6 

    The ratio of aldosterone-to-renin activity is currently recommended as a screening test for primary aldosteronism (PA). There are many factors interfering the interpretation of aldosterone-renin ratio (ARR) and could hamper in-time diagnosis of PA. Here, we first report a patient with underlying...

  • Long-Term Results of Adrenalectomy in Patients with Aldosterone-Producing Adenomas: Multivariate Analysis of Factors Affecting Unresolved Hypertension and Review of the Literature. Lumachi, Franco; Ermani, Mario; Basso, Stefano M. M.; Armanini, Decio; Iacobone, Maurizio; Favia, Gennaro // American Surgeon;Oct2005, Vol. 71 Issue 10, p864 

    The long-term surgical cure rate of patients with primary aldosteronism varies widely, and causes of persistent hypertension are not completely established. We reviewed retrospectively charts from 98 patients (range, 19-70 years old) with aldosterone-producing adenomas who underwent unilateral...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics