Laboratory-Acquired Dengue Virus Infection—A Case Report

Britton, Sumudu; van den Hurk, Andrew F.; Simmons, Russell J.; Pyke, Alyssa T.; Northill, Judith A.; McCarthy, James; McCormack, Joe
November 2011
PLoS Neglected Tropical Diseases;Nov2011, Vol. 5 Issue 11, p1
Academic Journal
Case Study
The article presents a case study of a laboratory scientist patient who was referred to a public hospital after presenting with fever, myalgia, and a rash. The patient reported a bite from escaped nonbloodfed mosquito but denied needlestick injury or mucocutaneous contact with the blood/virus mixture. The author asserts that the case is the first reported where exposure during laboratory-based mosquito infection and transmission experiments has resulted in an acute dengue virus (DENV) infection.


Related Articles

  • Co-infections with chikungunya and dengue viruses: A serological study in Karnataka State, India. Shaikh, N.; Raut, C. G.; Manjunatha, M. // Indian Journal of Medical Microbiology;Jul-Sep2015, Vol. 33 Issue 3, p459 

    The article presents a study related to co-infections of chikungunya and dengue virus in Karnataka, India. Topics discussed include challenges related to co-infections of multiple viruses such as difficulty in diagnosis, common symptoms of the diseases such as fever with chills and swelling of...

  • Cities spawn epidemic dengue viruses. Gubler, Duane J. // Nature Medicine;Feb2004, Vol. 10 Issue 2, p129 

    This article reports about the major countrywide and regional epidemics of dengue and dengue hemorrhagic fever (DHF), that occurs in Southeast Asia every three to five years. Dengue viruses are the most important arboviruses causing human disease, with 2.5-3 billion people living in areas of...

  • Which of These Animals Is the Deadliest on Earth?  // Storyworks;Jan2016, Vol. 23 Issue 4, p15 

    The article focuses on mosquitoes which cause death by spreading malaria. Topics discussed include death of kings, warriors and other ancestors due to malaria; female anopheles causing malaria, deaths in Africa due to malaria, symptoms of malaria such as high fever and muscle aches; and lack of...

  • Aedes aegypti Saliva Enhances Dengue Virus Infection of Human Keratinocytes by Suppressing Innate Immune Responses. Surasombatpattana, Pornapat; Patramool, Sirilaksana; Luplertlop, Natthanej; Yssel, Hans; Missé, Dorothée // Journal of Investigative Dermatology;Aug2012, Vol. 132 Issue 8, p2103 

    The article discusses the role of dengue virus (DENV) vector mosquito Aedes aegypti's saliva in the enhancement of dengue virus infection in Human keratinocytes. DENV is a single-stranded RNA virus that belongs to the Flaviviridae family and causes dengue hemorrhagic fever and dengue shock...

  • Newly recognized mosquito-associated viruses in mainland China, in the last two decades. Hong Liu; Xiaoyan Gao; Guodong Liang // Virology Journal;2011, Vol. 8 Issue 1, p68 

    There are four principal arboviruses in mainland China. Two kinds of them are mosquito-borne viruses, namely Japanese encephalitis virus and dengue virus, which lead to Japanese encephalitis, and dengue fever/dengue hemorrhagic fever respectively; the other two are tick-borne viruses, namely...

  • Dengue Virus RNA Polymerase NS5: A Potential Therapeutic Target? Rawlinson, Stephen M.; Pryor, Melinda J.; Wright, Peter J.; Jans, David A. // Current Drug Targets;Dec2006, Vol. 7 Issue 12, p1623 

    Dengue fever (DF)/dengue haemorrhagic fever (DHF) is the most common arthropod-borne viral infection, where it is now estimated that 2.5-3 billion people world-wide are at risk of infection. Currently there is no available treatment, in the form of vaccine or drug, making eradication of the...

  • Replacing a Native Wolbachia with a Novel Strain Results in an Increase in Endosymbiont Load and Resistance to Dengue Virus in a Mosquito Vector. Bian, Guowu; Zhou, Guoli; Lu, Peng; Xi, Zhiyong // PLoS Neglected Tropical Diseases;Jun2013, Vol. 7 Issue 6, p1 

    Wolbachia is a maternally transmitted endosymbiotic bacterium that is estimated to infect up to 65% of insect species. The ability of Wolbachia to both induce pathogen interference and spread into mosquito vector populations makes it possible to develop Wolbachia as a biological control agent...

  • Superior infectivity for mosquito vectors contributes to competitive displacement among strains of dengue virus. Hanley, Katryn A.; Nelson, Jacob T.; Schirtzinger, Erin E.; Whitehead, Stephen S.; Hanson, Christopher T. // BMC Ecology;2008, Vol. 8, Special section p1 

    Background: Competitive displacement of a weakly virulent pathogen strain by a more virulent strain is one route to disease emergence. However the mechanisms by which pathogens compete for access to hosts are poorly understood. Among vector-borne pathogens, variation in the ability to infect...

  • Inhibition of Viral Gene Expression and Replication in Mosquito Cells by dsRNA-Triggered RNA Interference Caplen, Natasha J.; Zheng, Zhili; Falgout, Barry; Morgan, Richard A. // Molecular Therapy;Aug2002, Vol. 6 Issue 2, p243 

    Mosquitoes transmit numerous viral pathogens to humans including dengue virus which affects ∼50 million individuals per year. Inhibition of viral gene expression within an insect host could be used to block virus replication and subsequent transmission of the pathogen to humans. A naturally...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics