Partial response to anakinra in life-threatening Henoch-Schnlein purpura: case report

January 2011
Pediatric Rheumatology;2011, Vol. 9 Issue 1, p21
Academic Journal
Case Study
The article presents a case report of a 9 year old girl diagnosed with Henoch-Schönlein purpura nephritis. Laboratory test detected the patient had hypoalbuminemia and proteinuria. Her symptoms returned in spite of treatment with methylprednisolone, plasmapheresis and mycophenolate mofetil. The patient showed improvement on giving interleukin-1 antagonist anakinra, but relapsed on reducing anakinra and led to irreversible renal failure.


Related Articles

  • Treatment of Complicated Henoch-Schönlein Purpura with Mycophenolate Mofetil: A Retrospective Case Series Report. Nikibakhsh, A. A.; Mahmoodzadeh, H.; Karamyyar, M.; Hejazi, S.; Noroozi, M.; Macooie, A. A.; Gholizadeh, A.; Gholizadeh, L. // International Journal of Rheumatology;2010, Vol. 2010, p1 

    Background. Henoch-Sch¨onlein purpura (HSP) is the most common childhood vasculitis with an incidence of approximately 10 per 100 000 children. There is some evidence to support steroid therapy in the treatment of severe abdominal pain, severe nephritis, and central nervous system...

  • Prevention of renal disease in Henoch-Schönlein purpura: clear evidence against steroids. Hoyer, Peter F. // Archives of Disease in Childhood;Oct2013, Vol. 98 Issue 10, p750 

    The article offers information on the study related to Henoch-Schönlein purpura (HSP). It informs that during the early stages of the disease, renal involvement can be diagnosed in up to 40 percent of patients. It mentions that biomarkers are not available for the identification of patients....

  • Henoch-Schönlein purpura nephritis with nephrotic state in children: predictors of poor outcomes. Wakaki, Hitoshi; Ishikura, Kenji; Hataya, Hiroshi; Hamasaki, Yuko; Sakai, Tomoyuki; Yata, Nahoko; Kaneko, Tetsuji; Honda, Masataka // Pediatric Nephrology;Jun2011, Vol. 26 Issue 6, p921 

    Nephritis develops in 18-81% of Henoch-Schönlein purpura patients, and the long-term outcomes of this nephritis show great variation. A nephrotic state at disease onset has been proposed as a predictor of poor renal outcomes. We studied 42 children with Henoch-Schönlein purpura nephritis...

  • Clinical course of extrarenal symptoms in Henoch–Schönlein purpura: a 6-month prospective study. Outi Jauhola // Archives of Disease in Childhood;Nov2010, Vol. 95 Issue 11, p871 

    OBJECTIVE: To describe the extrarenal symptoms and clinical course of Henoch–Schönlein purpura (HSP). DESIGN: A prospective national multicentre trial with 6-month follow-up. PATIENTS: A total of 223 newly diagnosed paediatric HSP patients. RESULTS: Purpura was the initial symptom in...

  • Abrupt and durable remission of Henoch—Schönlein purpura nephritis with cyclosporine A. Georgaki-Angelaki, Eleni; Kostaridou, Stavroula; Lourida, Athanasia; Petraki, C.; Lagona, Evagelia // NDT Plus;Oct2008, Vol. 1 Issue 5, p300 

    Henoch–Schönlein purpura glomerulonephritis (HSP-GN) is a common form of systemic small vessel vasculitis in children. Although prognosis is usually favourable, the disease is occasionally associated with a risk of renal insufficiency. Various immunosuppressive agents have been used in...

  • Oxford Classification of IgA Nephropathy Is Applicable to Predict Long-Term Outcomes of Henoch-Schönlein Purpura Nephritis. Nasri, Hamid // Iranian Journal of Allergy, Asthma & Immunology;Dec2014, Vol. 13 Issue 6, p456 

    No abstract available.

  • Henoch Schnlein Purpuralı 137 Olgunun 10 Yıllık Retrospektif DeÄŸerlendirilmesi. Dnmez, Osman; Yıldırım, Nihal Sargın; Durmaz, Oğuzhan // Journal of Current Pediatrics / Guncel Pediatri;Aug2011, Vol. 9 Issue 2, p63 

    Introduction: In this study, we have evaluated laboratory, clinical characteristics, and results of Henoch Schonlein's purpura (HSP) patients diagnosed in Uludag University Hospital Pediatric Nephrology outpatient clinic between 1999 and 2009. Material and Methods: The laboratory, clinical...

  • Treatment strategies and outcomes for Henoch-Schönlein nephritis: reply to Fujinaga et al. Kaito, Hiroshi; Ninchoji, Takeshi // Pediatric Nephrology;Feb2012, Vol. 27 Issue 2, p333 

    A letter to the editor is presented in response to the article "Treatment Strategies for Henoch- Schönlein Purpura Nephritis by Histological and Clinical Severity" by T. Ninchoji, H. Kaito, K. Nozu, Y. Hashimura, K. Kanda, I. Kamioka, Y. Shima, K. Hamahira, K. Nakanishi, R. Tanka, N....

  • Renal manifestations of Henoch-Sch�nlein purpura in a 6-month prospective study of 223 children. Jauhola, Outi; Ronkainen, Jaana; Koskimies, Olli; Ala-Houhala, Marja; Arikoski, Pekka; H�ltt�, Tuula; Jahnukainen, Timo; Rajantie, Jukka; ?-rm�l�, Timo; Turtinen, Juha; Nuutinen, Matti // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Nov2010, Vol. 95 Issue 11, p877 

    Objective To assess the risk factors for developing Henoch-Sch�nlein purpura nephritis (HSN) and to determine the time period when renal involvement is unlikely after the initial disease onset. Design A prospective study of 223 paediatric patients to examine renal manifestations of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics